If elderly hypertensive patient is non alcoholic and no gall stone on USG presented with features suggestive of the acute pancreatitis ,what will be the most possible risk factor for the development of acute pancreatitis.?
I saw some case reports about this. You may have a look at family history, which the first risk factor. Also, there is a strong link between fatty acids and inflammation, through ER stress. I think you should get some literature on the topic, wich is quite dense.
Good luck.
Hypertriglyceridemia causes pancreatitis.
The exact mechanism is unclear but we believed that this involves increased concentrations of chylomicrons (CM) in the blood. When triglycerides levels more than 1,000mg/dL, CM are almost always present. They are very large and may obstruct capillaries causing the ischemia . This local damage can expose TG to pancreatic lipases. The degradation of TG to free fatty acids can lead to cytotoxic injury resulting in further local injury that increases inflammatory mediators and free radicals, finally manifesting as pancreatitis.
Hypertriglyceridemia (HG) is the cause for 1-3% of all cases of acute pancreatitis (AP). AP is more common when triglycerides levels are > 1000 mg/dL. The family history of HG is crucial. The increased concetrations of chylomicrous in the blood ( primary or secondary due to ethanol) procuce AP.
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