Upper gastrointestinal (UGI) cancers are within the most common malignancies worldwide. About 10% of gastric cancers and 7% of esophageal cancer patients show familial clustering. We aimed to further elucidate the familial risk based on specified tumor locations. Our data shows family history of UGI cancers in some specific locations like upper and middle third of esophagus, body and antrum of stomach can be considered as an important predictive evidence for the same cancers in relatives. Any axperiences or idea in this regard will be appreciated.
Best regards,
Masoud
Familial inheritance has been found un Barrett's esophagous, which is a known precancerous condition related to gastroesophageal reflux disease. We found in a recent multicentric study that 1st degree relatives of patients with Barrett's have an increased risk of this condition which is linked also to some dietary habits.
Gastric cancer is strongly related to H. pylori infection. It is very frequent to bde infected in familial environment in childhood. On the other hand, European Guidelines on H. pylori infection management strongly recommend bacterium eradtication in 1st degree relatives of patients with gastric cancer.
I am not able to comment on locations in stomach but there is strong familial inheritance .
most of cancers related to common enviromental situation as arisk factors , agree with DR Enaz
- Badges
- Science topic
- Similar topics
- Biological Science
- Histology