Hello,
I have heard that the SARS-COV-2 virus attacks the hemoglobin molecule, but if this is the case, why do most infected people recover? Simply saying that the virus targets hemoglobin molecules does not explain much. I mean, an alternative explanation could be that the virus causes the red blood cells to become leaky, or that the virus somehow weakens the structural integrity of the membrane so that it ruptures during passage through the lungs. Yet, no matter what mechanism is postulated, there is still no good explanation for why only certain individuals die from the disease. The "underlying condition" catchall does not pass muster, either, since some healthy individuals also succumb.
Ventilators seem to do more harm than good. Perhaps the solution is something as simple as the pH of the blood or some other equally obvious facet of blood chemistry that has gone slightly awry.
Regards,
Tom Cuff
There seem to be quite a lot of theories about this; another theory put forward is recorded in this paper:
wenzhong, liu; hualan, Li (2020): COVID-19:Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.11938173.v8
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
If my understanding of this paper is correct, it suggests that it is linked to the haemoglobin affecting the ability of it to carry oxygen and the deoxyhemoglobin is more vulnerable to viral attack. However, this paper has been released for academic discussion and the authors welcome further experimentation.
This link also about haemoglobin also questions the use of ventilators if used "in a non-proper manner":
https://webcache.googleusercontent.com/search?q=cache:hJju50tESaAJ:https://www.thailandmedical.news/news/must-read-research-reveals-that-covid-19-attacks-hemoglobin-in-red-blood-cells,-rendering-it-incapable-of-transporting-oxygen--current-medical-protoco+&cd=2&hl=en&ct=clnk&gl=uk
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173
Probably corina virus is causing pneumonia like conditions and affecting myocardiac functions. Thus, those who have poor immunity with othor complications dying either fue to hypoxia (lungs choke) or heart problems or both.
https://www.thailandmedical.news/news/must-read-research-reveals-that-covid-19-attacks-hemoglobin-in-red-blood-cells,-rendering-it-incapable-of-transporting-oxygen--current-medical-protoco
« In healthy individuals, endothelial cells help regulate blood pressure, prevent inflammation, and inhibit clotting, in part through the continual production of nitric oxide (NO); they also serve as gatekeepers for molecules passing in and out of the bloodstream. When SARS-CoV-2 enters the lungs, it invades cells in the air sacs that transfer oxygen to the blood. Surrounding those sacs are capillaries lined like bricks with endothelial cells. The virus directly invades some of those cells; others become “activated,” likely in response to signals from the invading virus and other damaged cells. Injured, under CoV2 attack, they send out a complex array of signals to immune cells and clotting factors, which rush to repair the site. Damage and other changes in the activated cells trigger vascular leakage, flooding the air sacs with fluid, a hallmark of ARDS. White blood cells swarm to the lungs and NO production plummets»-Science, CM, 02.06.2020
https://www.sciencemag.org/news/2020/06/blood-vessel-attack-could-trigger-coronavirus-fatal-second-phase
« This mechanism could explain why the disease pummels some patients who have obesity, diabetes, and cardiovascular conditions: The cells lining their blood vessels are already compromised. If so, drugs used to treat these conditions might help prevent other COVID-19 patients from sliding into serious disease »
Following the up-mentioned collegues findings, we are pleased to suggest, in all modesty, our teams' posible contribution to an endothelial protection (NOs) :
Article All-trans retinoic acid stimulates gene expression of the ca...
Conference Paper Natriuretic peptide and other cardio-protective genes are st...
So: Should COVID-CoV2, be called Severe Acute Circulatory Syndrome (SACS) rather than SARS ?
Daniel do you use any protein producing cells.... ? any theories on what happens to protein production on increasing humiidity... to proteins being produced.
Available literature on microbial physiology states the protein production is inhibited. so SARS-Cov2 viral replication is inhibited. this partially formed viral particle can be recognised by our immune system. So steam inhalation should offer much better protection even if done for 5 minutes per day three times and might be leading to serotype specific vaccination is the hypothesis of our group.
understanding and proposition is theoretical.