Manganese is critical for proper early brain development while lead is neurotoxic... however, is there interplay between the two that anyone is familiar with in their experience or in the medical literature?
The only thing I've found so far is Pb decreasing manganese superoxide dismutase (Mn SOD) in the hippocampus, which is one of the areas of the brain that is primarily targeted by Pb
In general, I suppose lead will have not a great interference, because of different ionic radius of Pb(2+) and Mn(2+)..
I suppose it will not be a great intererence because of different ionic radius of Pb2+
and Mn2+.
They definitely interact. You can read a review here (starting p.8) made by ATSDR :http://www.atsdr.cdc.gov/interactionprofiles/ip06.html.
It seems that Mn could mobilize Pb. How they interact? It's not clear yet.
Thank you... we're seeing some overlap that suggests they do. For instance, blood Pb and blood Mn by gender seem to be almost have an inverted relationship (preadolescent males have high Pb and lower Mn while girls have the opposite). Some significance in Pearson correlation after testing the crude means so soon we'll be looking at covariates
The how part is really vital since I'm trying to do covariate analyses! But I guess that's part of the search
Many thanks, Marc
No problem! I also found interesting result regarding Mn and Pb. In my paper (Fraser et al. 2011), we observed less Mn in mussels in sites were Pb was high.
What you found seems very cool. I'm very interested in the effects of metals on biological systems according to organism sexes !
I have found that Mn in hair is lower in famales respect to males.without a correlation with Pb. Someone have an explanation?
That's a bit strange to me... males seem to have lower blood Mn levels than females in my own data and the literature I've seen
I'd expect it to be the opposite case
http://www.ncbi.nlm.nih.gov/pubmed/25596656
Luis: Are these adult patients?
Perhaps the manganese you are seeing in hair samples is a toxic form that is resulting from pollution or occupational exposure? That is seen to a higher rate in males. Trace elements in the hair often represent long-term excretion of toxins so it could be that males are being exposed to more of the industrially-derived forms of manganese as opposed to something dietary as an essential trace element
There were not exposed patients and with good health, (some had a little depression)
That was what arose my curiosity.. For hair analysis, take care with the cleaning
( there is a reccomended methods from The International Atomic Energy Commission).
it could be a washing issue... maybe double check that to see if it's a good possibility contamination was a factor
the only other factors I could think of would be diet, exposure, or possibly something hormonal
I doubt you'd miss that or something like menopause and you said they are all healthy subjects, however... maybe look into diet and their regional pollution situation
We have no problem of regional pollution.,neither diet ,. May be your suggestion of hormonal aspect may be studied..
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