In the ongoing project focusing on the design of a Prosthetic Heart and Venous Valve, our objective is to enhance the optimization of the materials used. Our focus is to prioritize materials with the highest level of durability. Following the acquisition of secondary values from the samples tested in the controlled environment, we will process this data digitally and conduct comprehensive fatigue analyses of the entire structure. In this fatigue analysis, our intention is to introduce the load as a cycle with variable amplitudes. While the ANSYS Mechanical program allows for variable amplitude definition, it restricts the load to a single surface, which is not in line with our preferred approach. Moreover, the ABAQUS Fe-safe program does not permit variable amplitude definition. We are thus inquiring whether any prior research has been conducted on a similar scale, yielding accurate results. Is such an analysis possible?