Hi all
I've encountered some little problem with CYP2E1
Many review and research have stated that ethanol may be potential to increase protein stability of CYP2E1,
And their conclusion are based on the result that they have obtained
such as low degradation rate and extend of CYP2E1 activity
But I can't seem to find the direct correlation between CYP2E1 and ethanol
Does anyone have any clue how ethanol increase its stability?
It may be an indirect mechanism - a low degradation rate and consequent increased activity of aged preparations may be due to a decreased stability of contaminating proteases present in the preparation.
Thank you Annemarie , I also think it's an indirect mechanism,
but my lecturer informed me that ethanol is capable of increasing CYP2E1 translation rate, but not in transcription rate
So is it possible that consumption of ethanol may degrade the proteomase of CYP2E1? or is it simply that the binding between CYP2E1 and ethanol that inhibits the proteomase binding to CYP2E1?
It is a common observation that proteins can be stabilized by binding to their ligands. Since CYP2E1 metabolizes ethanol, stabilization of CYP2E1 may be due, in part, to this ligand-induced stabilization phenomenon - a direct mechanism.
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