Hello Meilani Salsabila Daulay
You may get detailed information on google. Nevertheless, I came across this review article which is attached below. I suggest that you should go through it.
https://www.frontiersin.org/articles/10.3389/fonc.2022.960317/full
A key mechanism of action of many chemotherapies is the induction of DNA damage which leads to the activation of cell death pathways.
Conventional chemotherapies are divided into several classes based on their primary mechanism of action. They include:
1. Alkylating agents and platinum analogues, which induce inter- or intra- strand DNA crosslinks that destabilize DNA and cause DNA breakage,
2. Antimetabolites that inhibit the synthesis of DNA, RNA or their components,
3. Topoisomerase inhibitors that block the DNA unwinding enzymes, and
4. Microtubular poisons that act on tubulin, impeding the mitotic spindle and stalling cell division.
These drugs also have known secondary mechanisms of action, such as effects on mitochondrial biogenesis or the production of reactive oxygen species, which contributes to their cytotoxicity.
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