How to remove DCU and HOBT from my reaction?

I am doing a acid and a chiral amino alcohol reaction using DCC and HOBT in DCM or THF? Can anyone suggest me how to remove DCU and HOBT from a reaction mixture??

28 February 2021 2,153 1 View

Methodological confusions regarding deductive and inductive reasoning, hypothesis and theory test?

Hi Colleagues- What do you think about the following methodological issues: 1. Is it methodologically wrong to formulate quantitative research questionnaire based on inductive reasoning? 2. Is it...

21 February 2021 4,634 6 View

How the standard hydrogen electrode value is convertible into reversible hydrogen electrode?

As much I remember +0.0592*pH, as I am working on CatMAP, so my voltage values are in SHE, not RHE.

18 February 2021 1,685 3 View

Train-test split numbers for YoloV3/V4 models?

Dear Research Community, What are the common numbers (in percentages) for splitting the image dataset for training a Yolov3/V4 models? Is there a formal research on this question? Azmyin

08 February 2021 647 3 View

How are the anchor sizes defined in YOLOv3 and YOLOv4?

Dear research community? How are the anchor sizes defined in the cfg files of YOLOv3 and YOLOv4 object detectors? For example from the Yolov4 cfg file...

22 January 2021 4,504 1 View

What are core advantages of 2nd & 3rd generation panel data techniques over the 1st generation techniques?

I am interested to know about the difference between 1st and 2nd and 3rd generation panel data techniques.....

31 December 2020 7,204 7 View

How to construct a combined contour plot of two different text files in python?

As I constructed sperate contour plot for each methane and ethanol but now I wanna draw a combined plot for methane/ethanol ratio (for selectivity purpose)?

30 December 2020 4,531 1 View

Technically is there any difference between policy implications and policy recommendations?

Usually we use the two terms interchangeably in our articles but whether is there any technical difference between them?

26 December 2020 185 18 View

Modeling several ODE in matlab to create a system?

Please I have 4 groups of 8 sets of differential equations that I want to use for simulations. Each set has 8 differential equations to form a group. Each group is coupled with another group...

14 December 2020 8,193 10 View

What are the tools and techniques for making Custom dataset for YOLO?

Dear Research Community. I am new to the field of deep learning based object detection techniques. At this time, I am working on a project which will not use front-facing camera to detect people....

13 December 2020 957 3 View

SPPS: peptide failure to elongate?

SPPS of a 16 aa peptide was performed on a 0.15 mmol scale. Resin gained a minimal amount of weight: starting weight of 224 mg and a final weight of 280.I believe my peptide failed to elongate but...

21 December 2020 9,428 11 View

How to perform in silico peptide cyclization reactions by ChemAxon Reactor?

24 April 2020 9,398 1 View

Short Peptide synthesis, Fmoc-SPPS wth citrullin, why can it show a different mass?

I tried Fmoc-SPPS with short cyclicPeptides (12 aa length, Brom-Acetyl at the start for cyclization), for the first time containing citrollin. Many of the petides show a main Peak at the MALDI MS...

31 March 2020 3,986 3 View

How imide is formed by reaction between 4-nitrophthalic anhydride and melamine by using one mole of both?

I have performed this reaction many times by using acetic acid as a solvent bt no cyclization occurs to form imide.

05 March 2020 6,051 3 View

Difficulty in Getting Oximes?

I am trying to synthesis Oxime from beta keto ester. Although it's a very simple reaction but I could get the product in my reaction. II tried many methods but every reactions I get cyclized...

05 June 2019 6,720 6 View

How to remove diphenyl ether from reaction mixture?

Hi all. I have been using diphenyl ether as the solvent for my cyclization reaction. I would like to know how to remove diphenyl ether from the reaction mixture (about 3-4 mL), and my compound...

03 April 2019 7,693 8 View

Quick isolation of basic peak on an antibody?

Im working on an antibody that has a strange basic peak that does not come down after CpB treatment. After treatment, the peak averages at 5%. I attached pictures below. Mainly interested in the...

11 December 2018 5,634 2 View

What is the best mobile phase that can be used for the TLC separation of polyketides?

I'm trying to isolate some polyketides from Fungi and I need to know what is the best mobile phase that can be used for the clear separation and identification of Polyketides on TLC plates and...

05 June 2018 5,397 3 View

Which on is the good solvent for precipitation ?

I have amidation reaction in DCM using DCC. I can separate the bi-product through centrifuge or filtration. I am wondering what is the best solvent to precipitate the product ? either using cold...

09 April 2018 4,770 4 View

Which on is the good solvent for precipitation ?

I have amidation reaction in DCM using DCC. I can separate the bi-product through centrifuge or filtration. I am wondering what is the best solvent to precipitate the product ? either using cold...

03 April 2018 2,549 4 View