I want to react imine bond (schiff base compound) with thioglycolic acid and there is ortho substituent (-C2H5) in amine sction . Could this reaction happen easily? Could ortho- C2H5 substituent effect as steric effect?
Thioglycolic acid doesn't have a ketone or aldehyde so can't make an imine directly with that molecule. What is your specific reaction? Usually imines form well by driving off the water formed using toluene and a Dean-stark apparatus.
I already have imine derivative product from reaction aldehyde with ortho-methyl amine and l want to add thioglycolic acid to schiff base to produce thiodiazole is the methyl group prevent this