Dear all,
I need to develop a method (by LCMS/MS) to analyse meropenem in plasma
I do not have any experience with this compound and I was wondering if you could help me. I would need to stabilty the samples using some kind of stabilizer. According the literature, zwitterionionic buffers should work (I do not understand why). For this reason, after taking the samples I am thinking of using MOPS or HEPES buffer. For example: 50 µL plasma + 50 µL 0.5 M MOPS pH 7.2 (or HEPES pH 7.0). Then I would like to follow by MS/MS meropenem and its degradation products and see if the stabilizer is working.
Do you think this could work? Do you have experience with this?
How this buffers work on the stability of meropenem?
Thanks a lot for your time!!
Kika
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