Hello everyone,
Does anyone have any recommendations on how to calculate a diffusion coefficient from drug release data? I know that I will acquire the drug release over time and with this I can perform a mean least squares test to determine which kinetic model (Korsmeyer-Peppas, ect) is best fitted. This is where I am stuck, how do I get a diffusion coefficient from this kinetic model/data?
This isn't my usual background so I am struggling with this, any help would be greatly appreciated.
Cheers,
Sabrina
Dear Sabrina Schaly
I think the following link will be useful for you
https://link.springer.com/chapter/10.1007%2F0-387-31910-7_4
Best regards
You would have to linearize the equation to be able to apply a linear regression and find the kinetic coefficient.
Korsmeyer-Peppas equation: Mt/Minf = K t^n
Linear Korsmeyer-Peppas equation: log (Mt/Minf)= log K + N log t
If you plot on the x-axis [log t] and on the y-axis [log(Mt/Minf)], the slope of the line is the logaritm of the kinetic coefficient.
I recommend you a couple of articles, we apply this and other models:
https://www.researchgate.net/publication/352490116_Supercritical_Impregnation_of_Ketoprofen_into_Polylactic_Acid_for_Biomedical_Application_Analysis_and_Modeling_of_the_Release_Kinetic
https://www.researchgate.net/publication/353143757_In_Vitro_Study_of_the_Release_of_Drugs_Impregnated_by_Supercritical_Technology_in_Polylactic_Acid_for_Biomedical_Applications
Also check this chapter book:
https://www.sciencedirect.com/science/article/pii/B9780081000922000059?via%3Dihub
Kind regards
Dear, here I suggest this article. Kindly go through it. Might be helpful to you :)
https://findresearcher.sdu.dk:8443/ws/files/135970994/Experimental_determination_of_drug_diffusion_coefficients_in_unstirred_aqueous_environments_by_temporally_resolved_concentration_measurements.pdf
- Badges
- Science topic
- Similar topics
- Phytochemistry
- Extracts