The accuracy of glucometers can be assessed by adding interferences to the samples and comparing the results obtained by the glucometer with a reference method or standard.
To calculate the accuracy of the glucometer, the following steps can be taken:
Obtain a sample of blood or other fluid from a patient or donor.
Add a known amount of interference, such as a medication or chemical, to the sample. The interference should be chosen based on the likely interferences that the glucometer might encounter in a clinical setting.
Measure the glucose concentration of the sample using the glucometer.
Measure the glucose concentration of the same sample using a reference method or standard, such as a laboratory analyzer.
Compare the results obtained by the glucometer with those obtained by the reference method. The difference between the two measurements is known as the bias.
Calculate the accuracy of the glucometer by calculating the mean bias, as well as the standard deviation and/or coefficient of variation of the bias.
It is important to note that the accuracy of a glucometer can be affected by various factors, including interferences, temperature, and humidity, among others. Therefore, it is important to conduct accuracy assessments under a range of conditions to ensure that the glucometer is reliable and accurate in real-world settings.