We are seeing some sex-specific differences in cardiovascular variables with aging. These differences might be explained by changes in the concentration of sex steroids with aging.
There are many changes, not only lasting from two months but from postnatal day 1 to seventh postnatal day and beyond in the male and female rats, also in preadolescence; these differences modulate play, ulterior reproduction, neurogenesis, plasticiity, astrocytic function and much more other processes, and -of course- during midlife and aging. There are many papers and reviews that document these arguments and other more specifically affecting to neural vascular function (pathological vasculogenesis) and properly modulating or at least affecting the cardiovascular function. The astrocytic protein S100B (affected by sex steroids not only in development but during aging) is a regulating factor centrally and/or peripherally in several alterations and cardiopathies.
Perhaps, you may tray to combine these all variables or keys in your search.
¡Good luck in it!
A number of articles have ben published to illustrate thee changes in sex steroids with age, you might find these helpful
1. Steger RW, Peluso JJ. Effects of age on hormone levels and in vitro steroidogenesis by rat ovary and adrenal Exp Aging Res. 1982 Fall-Winter;8(3-4):203-8..
2. Döhler KD, Wuttke W. Changes with age in levels of serum gonadotropins, prolactin and gonadal steroids in prepubertal male and female rats. Endocrinology. 1975 Oct;97(4):898-907.
3. A. T. M. Konkle and M. M. McCarthy, “Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain,” Endocrinology, vol. 152, no. 1, pp. 223–235, 2011.
All the best.