How do I induce type 1 diabetes in mice?

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Which animal model is best to study regeneration of beta cell in type 1 DM?

STZ induction mouse or rat ? how about NOD mouse or BB rat? Is there any method for viral induction ? which one will be closest to mimic natural b cell destruction ?

05 June 2015 7,341 5 View

Please explain how the plastic input value should be considered from the true stress-strain curve for the bilinear elastoplastic material model ?

I am working on Abaqus/Explicit(Quasistatic ) for the deformation of the auxetic structure model. Please explain how the plastic input value should be considered from the true stress-strain curve...

05 August 2024 454 3 View

"A Markov-like Model for Patient Progression"?

A Markov-like Model for Patient Progression" Markov Chain Monte Carlo (MCMC) Markov Chain Monte Carlo (MCMC) is a powerful computational technique used to draw samples from a probability...

05 August 2024 10,079 0 View

How to report results of Generalised Linear Mixed Models in a journal article?

Hi everyone, If you have written or come across any papers where Generalised Linear Mixed Models are used to examine intervention (e.g., in mental health) efficacy, could you please share the...

04 August 2024 4,130 4 View

How to isolate lymphocytes from mouse spleen?

I have tried several times to isolate lymphocytes from mouse spleen, but all attempts have been unsuccessful. I tried most available protocols. I used different dissociation media (HBSS with Ca...

04 August 2024 9,913 7 View

Is it necessary to covary exogenous constructs in a structural model?

I am working on a SEM model where i have 7 latent variables (6 exogenous and 1 endogenous). In AMOS when I co-vary the exogenous constructs, only 2 paths are coming significant out of 6. But when...

03 August 2024 6,028 4 View

Why can't academics earn the money they deserve?

Only Journals make money from the articles we have worked on for years. Academics do not earn money from their refereeing. Then shouldn't the solution be a system in which academics can earn...

01 August 2024 6,469 6 View

Posthoc test lettering in JAMOVI?

Does anyone know of a module for the JAMOVI software that is capable of generating mean separations using the classic letters based on post hoc results (e.g., Tukey test)? If, as I believe, such...

31 July 2024 3,333 4 View

Where to download DEM from 2018?

I am currently working on validating land subsidence results obtained using SBAS InSAR. Could anyone suggest reliable sources or repositories where I can download a historical DEM from 2018?...

31 July 2024 9,757 3 View

SAS Generalized Linear Model for trial/event anaysis and not survival (time to event) analysis?

I am looking for a published article using SAS or SPSS Generalized linear model for trial/event data and not survival analysis. Both software packages off the option for the number of success out...

30 July 2024 3,835 2 View

What are the perfect mathematical model for a solar-powered ship implementation?

A computational study of heat flux on cylindrical surfaces using CNT hybrid nanofluids

28 July 2024 4,985 1 View

Prabu Paramasivam

Dear Niraj Chaudhary

Regarding your question.

Please check ResearchGate featured Question

Which type of diabetes will be induced by Streptozotocin in experimental rat models?

you will get more information.

Gregory Dressler

Injection of a single dose of streptozotocin will kill insulin producing pancreatic islet cells. There are many papers on this so you need to look up the doses and timing for your strain of mice.

Regouat Nadia

injection of alloxan or strptozodocin induce apoptose of B pancreatic cells, but in this case it is an experimental diabetes because there are studies that demonstrated the persistence of some B pancreatic cells