From a hosts point of view, which comes first, effect of toxins on pathways or identification of toxins?

From a pure biology perspective, when a pathogen affects a host, what comes first, the effect of the toxin (effector protein) on the pathways or identification of the structure of the toxin by the...

01 February 2020 8,453 6 View

How do you apply statistical testing when predicting effector proteins?

Being a computer science student, I don't know much about statistical testing. However, recently, a lot of work has reported statistical validation of their result. In machine learning-based...

10 November 2019 6,264 2 View

How to download from NCBI the FASTA of all sequences for a particular search term?

After a search term is entered, on the top right there is an option called Send to. Then click File, and click FASTA under format tab. There they show you how many entries/sequences to be...

05 June 2019 6,191 2 View

Someone help me to find one gram-positive non-pathogenic bacteria residing in human gut along with a reference claiming the same?

I want to know the names of a few species of gram-positive bacteria which are non-pathogenic and and lives in the human gut....

04 May 2019 9,236 2 View

Where can i get all the proteins (amino acid sequence) and their corresponding nucleotide sequence of Bacillus subtilis?

I want a list of all the peptide and their corresponding nucleotide sequences of Bacillus subtilis In the fasta format.

04 May 2019 4,431 3 View

What is the example of a gram-positive non-pathogenic bacteria?

I want to know the names of a few gram-positive non-pathogenic bacteria

04 May 2019 8,244 2 View

In order to establish a new metric for quantifying something, what are the prerequisites?

Suppose I want to establish a new metric for a certain bioinformatics problem. What are the mathematical prerequisites for establishing this metric? Are lemma's and theorems required for...

01 February 2019 1,953 2 View

How does binding between 2 proteins occur?

Suppose 2 genes produce 2 proteins which would be binding. After the genes are turned on and the proteins are produced, then genes can be turned off and the proteins produced can bind with each...

01 February 2019 8,742 6 View

When a protein binds to the dna or a particular gene, does the gene need to be activated in order to bind?

So proteins bind to DNA or genes all the time. I wanted to know whether before binding with a protein, the gene needs to be activated or not. If there is a research article backing your claim,...

31 December 2018 1,180 3 View

What is the impact factor of journal of bioinformatics and computational biology (world scientific)?

Got a research gate score, but I want to know its actual impact factor. Is it a good journal in Bioinformatics?

10 November 2018 2,063 3 View

How to compare two groups with only two measurements?

Hiiiii everyone! I have an enquiry on statistical analysis. I was looking for many forum and it's still cannot solve my problem. I want to compare means of two groups of data but only with two...

03 March 2021 8,796 3 View

Looking for Materials with high thermal expansion coefficient and high temperature resistance?

03 March 2021 8,272 1 View

Can we classify HV and LV lines based on line length?

I have dataset which shows the length of power lines. I need to classify the lines based on the line length. Is there a rule to classify the High voltage (HV) and low voltage (LV) lines based on...

03 March 2021 4,116 4 View

Why does blocking with my immunogenic peptide cause nuclear fluorescence in ICC?

Hi all, I am validating a polyclonal antibody raised against human ANT4, through WB and ICC. In most of my controls, the antibody shows very little off-target binding, but when I pre-incubate the...

03 March 2021 5,999 3 View

Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence?

I am on the lookout for the Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence. Does anyone know where I can find it? Thank you in advance

03 March 2021 3,568 1 View

What kind of fluid could I use for a pitfall trap that also does not invalidate molecular testing?

Hi, I want to start testing pitfall trap to obtain ants samples, but I need to conduct molecular analysis on those insects. So, what kind of fluid can I use? Ethanol expires too early and I need...

03 March 2021 5,978 5 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

Do we need to write protocol for a second study of a systematic review that has been registered and published?

I have conducted and published a systematic review and meta-analysis research with the topic related to public health and health pomotion (protocol was registed in PROSPERO). Now we want to...

03 March 2021 8,920 3 View

How to increase a model accuracy ?

dear community, my model is based feature extraction from non stationary signals using discrete Wavelet Transform and then using statistical features then machine learning classifiers in order to...

03 March 2021 6,994 5 View

What solvent can I used for Paal Knorr reaction between 6-amino hexanoic acid and 2.5 hexanedione?

I am try to make the Paal Knorr reaction between 2.5 hexnedione and 6-amino hexanoic acid, my problem is type of solvent to use, because 6-hexaminohexanoic acid is soluble in water but I am not...

02 March 2021 4,443 2 View