Hey Shruthi. Try to search in Veterinary Pharmacology Textbooks. The Pharmacodynamic sections will provide you with basic information on the ligands of interest. once you find your ligand, Try to search in publications on Pubmed or Google scholars for these ligands for adults and young animals. Best of luck.

Hi Shruthi

I have in my past life heard/learnt at Vet school about dog condition similar to Duchenne muscular dystrophy reported in golden retrievers.

Duchenne muscular dystrophy (DMD) is neuro-muscular disease caused by a genetic problem in producing dystrophin, a protein that defends muscle fibers from breaking down when exposed to enzymes in muscles and particular regions of CNS. DMD occurs mostly in young males, though in rare cases may affect females. The symptoms of DMD include progressive weakness and atrophy of both skeletal and heart muscle. Respiratory insufficiency contributes to morbidity of muscular dystrophy and, along with cardiomyopathy. In dogs, condition was originally reported in golden retrievers and termed golden retriever muscular dystrophy (GRMD).

Here you can read PMID: 33071066 about study performed on young dogs

Here is more about the disease PMID: 11834588

You may decide after all reading to check GRMD more closely, if there are studies showing comparison of young pups vs. older and how they are neurologically examined by Vets in the clinic. Hope this helps

Filip

sorry, I do not understand your question

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