Hi everyone. I have designed a study with three separate steps. First I scan healthy people who passively receive rhythmic and non-rhythmic sequences in auditory and vibrotactile modalities. So two modalities and two conditions in each modality (4 conditions in total). Then I scan people with Parkinson's disease (PwP) who receive the same stimuli. Then I calculate the functional connectivity (using the Psychophysiological Interaction (PPI) method) during rhythmic tasks in each modality separately in both groups of people to see in which ways healthy and PwP people's FC might be different. After that same Parkinson's people get a rehabilitation method for their walking performance and the results of gait (walking) improvements will be correlated with FC values to see if the degree of FC can predict gait improvement following that specific rehabilitation method.
Now my question is:
1- How many people would be considered a good sample size for my study?
2- Is it preferable to have the same sample size in both healthy and PwP? if yes, why?
Hi Zhaleh
First question:
1. I need a pilot study, or
2. A similar study to yours
Second question:
It is better but not must to be the same to increase homogeneity of variances between groups
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