How do I adjust the 'p' value of haplotype association study for multiple testing?

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Zornitsa Kamenarska

Hi,

I recently dealt with Bonferroni corrections. Determine the threshold by deviding 0.05 to the number of SNPs or haplotypes (basically to the number of individual ANOVA tests you have performed) you have analized in that study!

Flora Dai

many thanks, yes i found that bonferroni corrections has been used in several papers. May i ask which program you use? i am considering that as the tested haplotypes are related, whether bonferroni is conservative?

Thank you so much, it is very helpful

Chong Ge You

Maybe you can use the online software of SHEsis(http://analysis.bio-x.cn/SHEsisMain.htm) which can generate the frequencies of single SNP and the haplotype of several SNPs.

Including P value in the software of SHEsis.