D614G mutation in spike protein of SARS-CoV-2 appears to be more deadly because it causes higher transmission rate of COVID-19.

There is circumstantial evidence that D614G mutation in the spike protein of SARS-CoV-2 is associated with a higher mortality (1). Because this mutation also increases the infectivity of the virus, with increased number of COVID-19 patients (2), total mortality also increases.

However, it needs a big multinational comparative study of the mutations in SARS-CoV-2 in different countries to define infectivity and mortality associated with different mutations.

1. Article Could the D614 G substitution in the SARS-CoV-2 spike (S) pr...

Preprint The D614G mutation in the SARS-CoV-2 spike protein reduces S...

Thanks for sharing!

Would like to know about the outcome of this research question

You can check out the 2 links Dr Muhammad Yousuf added in his reply.

Please have a look at this useful link.

https://www.nature.com/articles/s41586-020-2895-3

Dar Michael Halim in this context please also see this potentially useful link entitled "COVID-19:Variant found in UK may be more deadly than original virus - here's what we know"

https://news.sky.com/story/covid-19-should-we-be-worried-about-the-new-coronavirus-mutation-12161566

However, the question is still under discussion and has not been finally verified.

Please take a look. I think these links will help you a lot. Thank you.

https://doi.org/10.1016/j.cell.2020.06.043

https://www.nature.com/articles/d41586-020-02544-6

https://www.google.com/amp/s/www.newsweek.com/d614g-coronavirus-mutation-new-less-deadly-strain-1526165%3famp=1