For Covid-19, unlike other similar viruses, the mutation rate is 20 percent. This is not a big indicator. This is optimistic about the vaccine. It will be universal for all strain. Regards, Sergey Viktorovich Pushkin
The nature of COVID-19’s spike proteins are already thought to be the key reason why it was able to make the leap from a different species, widely thought to be bats, to humans in the first place.
Mutations arise when the virus replicates inside cells and mistakes are made in copying its genetic code. The good news is that the coronavirus is genetically quite stable. Up to now, there is no big mutations that affect the antigenicity of the virus like those occurring in influenza viruses so that we need a different vaccine each year. In conclusion, there is no real worry regarding the in-pipeline COVID 19 vaccines.