Hello, colleagues.
I observe several patients with SCN1A channelopathies, and among them there are 4 children of the same age and with birth dates in the interval of 2 weeks. Today they are about 5.5 years old. Interest is that all these four children are very high — they exceed the average height of their age by 10 — 20 cm, ranging from 122 to 135 cm. What could be the reason for this?
1. Everyone has this or that mutation in the gene SCN1A.
2. Everyone had a history or is taking the VPA now.
3. Everyone's parents are of average height.
I assume that the mutation has nothing to do with the growth. Perhaps this is the VPA. Perhaps some other factor. Who can say anything?
Hi Dr.
www.sciencedirect.com/science/article/pii/S1059131111001737
this link will help you
there are some links on the association between valproate exposure and length at birth in mothers treated with valproate during pregnancy, and some association studies that link AED exposure to growth restriction also, so perhaps not the cause, but the needed treatment ?
BMC Pediatr. 2013 Dec 19;13:211. doi: 10.1186/1471-2431-13-211.
The impact of the use of antiepileptic drugs on the growth of children.
Lee HS, Wang SY, Salter DM, Wang CC, Chen SJ, Fan HC1.
Serum levels of valproic acid during delivery in mothers and in umbilical cord - correlation with birth length and weight.
Kacirova I, Grundmann M, Brozmanova H.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Dec;159(4):569-75.
Dear Dr. Allegaert, thank you very much, I will look at these papers.
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