Hi,
I have stumbled upon an article about translocation of AKT into mitochondrial matrix upon IGF stimulation and as I tried to find some mechanism of this transport I found another articles about translocation of cytosolic proteins into mitochondria (GSK upon EPO treatment, HSP60 upon dehydratation).
I have always been taught in our cell biology lectures, that nuclear-encoded proteins are imported into mitochondrial matrix predominantly co-translationally and that only small portion of proteins are translated on free ribosomes but are kept unfolded by chaperones and then, still unfolded, transported into mitochondria, where they acquire native conformation.
Since this is not main focus of my work, but I find it interesting, I want to ask if somebody knows how well studied and how common this translocation of mature cytosolic proteins into mitochondria is and weather other such well-known proteins do this. And maybe suggest some review/article on this topic.
Thank you very much
Hi Klára Kořínková,
The protein precursors are synthesized in the cytosol and imported into mitochondria by multiple transport pathways. This review was published in 2017. Here you can find about mitochondrial protein import pathways. Article Mitochondrial Machineries for Protein Import and Assembly
BR
Jay
Thank you very much for our answers. I forgot to mention that I´m only interested in human cells. The TAT machinery seems not to be conserved in humans, so i guess its not the thing I´m looking for.
I´m also aware of te existence of pathways transporting unfolded precursor proteins into mitochndria. What I´am actually interested in is wheter there is some known pathaway that folded, functional cytosolic proteins use to translocate into (and possibly out of) mitochondria upon certain stimuli.
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