Selection of dose is depended on LD50 of that substance to be administered. However, the amount of orally administered drug reduced for its i.p., i.m., s.c., or i.v. administration route. What is the standard conversion technique to calculate those dosages from a typical 500 mg/kg oral dose? You can consider mice or rats as experimental animal.
You don't have a standard dose conversion from oral to i.p or sc or i.v. How much is required is all dependent on the drug's pharmacokinetic parameters. So many parameters influence the drug absorption like drug's formulation etc.
Generally, the dose is actually set by adminstering the drug in various different routes and find out the data like Cmax, Tmax, AUC etc. from various routes and then firstly we try to choose oral route because that is a preferred choice of drug adminstration in humans. Why do you want to use the drug in ip or iv or sc? Does that have absorption issues?
But once you get the data of Cmax, etc. you do the DRC (dose response curve) pharmacologically. LD50 comes after the pharmacological assays. Therapeutic index and all is a different story.
I agree with you and I know that. You can concern about preliminary screening of crude extracts or their fractions, even for some established drugs # Venkata Harsha Vardhan Boddeda.
No conversion factor between the different route of administration. For dose selection, you should find out MTD using same route of administration.
please note that there is no regression between this methods :
in oral admin. you may loose parts of effective elements rather than IP. or Im.
and remember that there are different drug physiological kinetics in different administration methods.
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