In industrial scale processes, huge quantity of solvents is used. The inefficiency in the recovery of the solvent causes problems with the economic viability of the process. How can one avoid the solvent loss at industrial scale?
The use of activated carbon for solvent recovery is well established for processes such as industrial-scale paint shops and printing works . When the carbon adsorbent eventually becomes fouled with contaminants which do not desorb during the normal regeneration cycle, it may be interesting to consider reactivation using "facilitated oxidation" in stead of conventional thermal reactivation. See www.acfox.com
Use of solid phase reactions you can able to reduce the solvents in any organic and long step reactions., I Don't know what is your working area, if it's organic reaction means you can able to use solid phase organic synthesis
By using this you will reduce >50%% of solvents. if you want more details regarding to this large scale solid phase synthesis and support contact me back.
Its possible and quiet simple even multiple reaction step..