How can i suspend Alginate particles in aqueous media for zeta potential meausurement ?

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Omkar S. Kushwaha

Dear Jan Bröckel

Ceating a suspension or microparticles in the form of hydrogel has been used for biopolymers.

You may refer to

1} Production and characterization of alginate microparticles obtained by ionic gelation and electrostatic adsorption of concentrated soy protein https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018001200750

2} The Synthesis of Alginate Microparticles and Nanoparticles https://lupinepublishers.com/drug-designing-journal/fulltext/the-synthesis-of-alginate-microparticles-and-nanoparticles.ID.000155.php

Titus Sobisch

if you want to characterize your particles, which dissolve in water it makes no sense to attempt zeta-potential measurements. What is the environment you envisage their use as particles?

Jan Bröckel

Titus Sobisch I am just confused because i found literature reporting zeta potential in aqueous solution of similar systems. The particles are supposed to be applied for nasal drug delivery.

Omkar S. Kushwaha I will have a look, thank you.

there maybe a difference in surface due to adsorption preventing dissolution