How can I predict the IC50 value for a ligand with the help of an occupancy value?

More Kishna Vijayaraghavan's questions See All

How can we do a Reverse Technology Process?

Target identification -> HTVS -> Glide XP -> e-pharmacophore mapping?

03 April 2014 5,186 0 View

How can I interpret HEX server protein-protein docking results?

I've got two files, *.hex and *.pdb files. I want to see the interactions between those two proteins. How can I see it?

03 April 2014 10,023 2 View

Does anyone know how PPAR-Gamma is related to Type II Diabetes?

see above

03 April 2014 337 3 View

Can anyone tell me what K-mean clustering means?

In what bases does K-mean clustering separate data?

02 March 2014 7,431 6 View

How can I generate a heatmap using the docked file data I have collected? .

Which server can use for heatmap generation? I have the docked file data (3 PDB files).

02 March 2014 9,878 0 View

Is there any software or online server to do cluster analysis ?

Cluster Software programs: I have a set of compounds ( say 10000 ); I want to cluster them or group them into certain properties( say structures). How can I group them? Is there any software or...

01 February 2014 2,048 3 View

Can I use e-Pharmacophore on any web server?

see above

01 February 2014 4,331 1 View

Does anyone know how to view the alignment results in ESPript?

I have given the clustalw (*.aln file) as input and given the submit button,but it doesn't shows any alignment result or images? How to view the output files?

01 February 2014 9,730 3 View

Can anybody provide a small paragraph about e-pharmacophore?

e-pharmacophore explanation.

01 February 2014 7,892 1 View

RIA. How to measure?

When you use RIA, with a control the unknown sample with antibodies, you bare in mind the binding sites of the antibodies. However you still need to measure labelled antigen (radioactive) and not...

28 February 2021 2,133 3 View

What is the difference between genotype and haplotype data in the ped format?

Hi everybody In the ped format for genotype, alleles of any SNP are represented by two columns (one for each allele, separated by a space). Is a column sufficient for the haplotype to...

27 February 2021 1,965 1 View

How to model Supercritical water gasification (SCWG) process in Homer software?

Hi everyone How to model Supercritical water gasification (SCWG) process in Homer software?

25 February 2021 4,075 1 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

Are there any databases for gene co-expression or expression pattern clustering?

I am currently working on gene clustering based on co-expression pattern in mouse brain. The problem is I do not have some solid way to test my result. Are there any suggestions for databases...

22 February 2021 4,374 3 View

What are the potential shell well and atomic solvation parameters for the boron atom?

I have a protein-ligand docking project. The ligand contains boron atoms that are not detected by Autodock software. To solve this problem, it is necessary to introduce the boron atom to...

19 February 2021 1,236 1 View

Any suggestions or recommendations on a good publishing house based on the African for academic books in the field of Communication and media studies?

I am currently working on a book on Public Relations (from an African perspective) and the rationale behind the book is the fact that as instructors in this field, we borrow instances and case...

19 February 2021 2,482 2 View

When to use different framework?

Hi, can I use both conceptual framework and theoretical framework in my systematic review? My future study plan is to use a theory. In this situation for my systematic review should I use both or...

18 February 2021 9,581 2 View

Person-Codes for questionnaires in longitudinal studies: Is there an easy solution for better matching-rates?

Hi, I have a problem regarding matching of longitudinal data in my field of research (university students). We have a Person-Code for matching data measured in different time points, but 30%+ of...

17 February 2021 3,075 4 View

Can anyone provide an advice on running a validation study of a commercially available product in collaboration with the manufacturer?

We are planning to run a study validating a commercially available product (i.e. software) and while we initially planned to do it independently of the manufacturer, they heard about our intention...

17 February 2021 2,295 3 View