Wistar rats treated with streptozotocin would die. They are too sensitive, you have to use sprague dawley rats.

i would suggest you try Streptozotocin and nicotinamide combination, it has work and you will surely be mimicking type 2 DM, another option is to go on high fat diet, this is also a model a friend of mine have used before and he got some wonderful result. lastly, try sucrose although you won't be mimicking type 2 DM but you have some features of it in this model. there are literature backing all these models. check them online

Streptozotocin 65mg/kg i.p route induction in wistar albino rats is a good model for Type II diabetes mellitus.

STZ is a TYPE 1 model. The pancreatic beta cells are killed, causing insulin deficiency, which is the definition of type 1. To model type 2, you should be using Ostuka Long-Evans Tokushima fatty rats (OLETF). They reliably develop obesity and insulin resistance, and there is a lean strain of these rats that you should use as a control. 

I use streptozotocin to induce diabetes in Long-Evans rats, because I model type 1, by injecting the STZ into the tail vein at a dose of 60 mg/kg in saline. The thing with this is that STZ is so effective that the rats often lose weight, which means they are starving. To counter this, we implant insulin under their skin at the back of the neck. I implant one half of a LinPlant (http://www.linshincanada.com/linplant.html) and implant extra ones whenever the rat's blood glucose exceeds 600 mg/dL. Furthermore, STZ is very unstable and must be mixed into ice-cold saline immediately prior to injection, and the mixing and injection should be done in the dark. 

I agree with Nicholas G Mitrou. Streptozotocin (STZ) can be used for the generation of Type 1 diabetes model. I used one time dose of 50mg/Kg of body weight (Intrevenous) in sprague dawley rats to generate type 1 diabetic model.

http://link.springer.com/article/10.1007%2Fs12257-013-0612-x#page-1 

However here is one article which will give clue for selection of diabetic agent

http://medind.nic.in/iby/t07/i3/ibyt07i3p451.pdf

In our experiment we induced type2 diabetes with STZ (35 mg/kg body weight) along with supplementation of high fat diet (35%) in wistar rats. Further details you can find the attachment. 

I agree entirely that STZ induces type 1 and not type 2 diabetes. Inducing type 2 is very complicated and time consuming. Would you want an obese or non obese type 2 model of diabetes? That is a question you need to ask yourself. You would be advised to procure one of the already established models of type 2, in most of which there is a genetic component involved. Your choice would depend on the aim and purpose of your experiments. Good luck, as this is no easy task 

Mohammad Mahdi Tavana

I have used the model of DM2 induction-STZ, in which manage Wistar rats STZ in Neonates, 48hrs after birth. The model is widely accepted and is evidenced DM2 with glucose intolerance. If you want besides the T2DM rats, lipid profile changes, you can associate a high-fat diet, this by helping the lipid and cardiovascular changes.

It follows two articles, one using Wistar neonates with the administered dose, and another on the models for T2DM:

1.Sartoretto JL, Melo GAN, Carvalho MHC, Nigro D, Passaglia RT, Scavone C, et al. Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression. Life Sci 2005;77:2676–89

2.Arulmozhi D, Veeranjaneyulu A, Bodhankar S. Neonatal streptozotocin-induced rat model of Type 2 diabetes mellitus: A glance. Indian J Pharmacol 2004;36:217.

Check out the papers by Vickers et al spanning over 10years regarding developmental programming of diabetes in rats. These paradigms are based on either maternal under or mal-nutrition or obesogenic diets during pregnancy. The outcomes are really about a broader spectrum of syndrome X including type 2 like diabetes, hypertension and dyslipidaemia. 

You can also use Zucker fa/fa rat as a type 2 diabetes model. It is a spontaneous genetic obesity model (mutation in the leptin receptor) and, by comparison with lean Zucker rat, exhibits hyperphagia, hyperinsulinemia, and hyperglycemia.

You can find Original Articles for your reference: Sophie Haliakon,

Liliane Doaré, et al Pioglitazone Induces In Vivo Adipocyte Differentiation in the Obese Zucker fa/fa Rat Diabetes September 1997 46:9 1393-1399

KK-Ay mouse is a very good T2D model. it becomes fat and hyperglycemic after 6 weeks. importantly, if  the test sample  is not plenty, using this mouse model but not rats model is your best choice. however, we all know these spontaneous diabetes models are expensive. STZ+HFD or nicotamide can induce T2D model in rats. you can refer the related papers.

In our experience neonatal Wistar STZ rats achieved a moderate diabetes in the adult animal similar to the human type 2 diabetes . There are various combinations of doses (70, 80, 100 mg / Kg), days (0, 2 5) and inoculation routes (sc, iv, ip) depending on the final objectives of the experiment. In all cases over the eight weeks the individual has hypoinsulinemia, hyperglycemia and eventually present other complications of the disease such as kidney damage, dyslipidemia, among others.

It is a long model, but not with high mortality.

Journal of Ethnopharmacology 115 (2008) 173–183

Sucrose 20% in drinking water will give you metabolic syndrome in one month. After 6 months treatment, fasting glucose will be high and metabolic syndrome will continue present (Larqué C, et .al., Early endocrine and molecular changes in metabolic syndrome models. IUBMB Life. 2011 Oct;63(10):831-9. doi: 10.1002/iub.544. 

Velasco M, et al., Metabolic syndrome induces changes in KATP-channels and calcium currents in pancreatic β-cells. Islets. 2012 Jul-Aug;4(4):302-11. doi: 10.4161/isl.21374.

Hello everybody.

Very good discussion and I enjoyed a lot. 

I have a question. How many days after induction of diabetes in rats, we could anticipate to have diabetic neuropathy?

Many thanks.

Type 2 diabetes can be induced by 60% animal fat high-fat diet. It works very well and is very reproducible. It might take 8 to 10 weeks feeding but the result is guaranteed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277487/