Sanmugapriya Ekambaram

10 Questions 44 Answers 0 Followers

Questions related from Sanmugapriya Ekambaram

Which is the alternate animal model for type II collagen induced arthritis in DBA/1 mice?

Is there any alternate animal model for type II collagen induced arthritis in DBA/1 mice? DBA/1 mice is not available easily and thus suggestion on any preferred animal model for the study is...

20 December 2016 5,191 2 View

What is the resistance mechanism adopted by MRSA ?

Other than PBP2a expression, is there any other resistance mechanism involved in MRSA resistance towards antibiotics?

14 November 2014 5,511 10 View

What are the storage condition for hydrolysable tannins obtained from plant species?

Hydrolysable tannins are expected to get converted to gallic acid and ellagic acid on long term storage. Is it true? What would be the storage condition then?

14 November 2014 7,251 5 View

Why are plant secondary metabolites less effective as antimicrobial agents when compared to drugs derived from other sources?

There is a lot of literature available on antimicrobial action of various plant secondary metabolites like flavonoids, tannins, triterpenes etc. Still, they are not competent enough with the...

05 October 2014 7,883 4 View

What is the significance of performing antiarthritic studies in human RA fibroblast like synoviocytes (RAFLS)?

Whether a drug proven to be effective in human RAFLS model can be directly taken to clinical trials?

04 October 2014 2,968 4 View

Has anyone collected synovial fluid from rats or mice while performing arthritic studies?

It is very difficult to collect synovial fluid from smaller experimental animals. I would thus like to know a best method to collect it. Kindly share the real, worked out, experienced methodology...

18 September 2014 5,236 4 View

How far an immunosuppressive phytochemical can be developed as an antirheumatic agent in overcoming the disadvantages of the existing drugs?

Is there any effective immunosuppressive phytochemical which can overcome the difficulties of existing immunesuppressants?

31 August 2014 2,650 4 View

What are the enzyme based effective therapeutic targets for Rheumatoid arthritis?

Cytokines are the effective therapeutic target for RA. Is there any effective enzyme based therapeutic target which has been studied in in vivo models?

27 August 2014 4,040 5 View

Is there any structural criteria in drug substances that may be responsible for an efflux pump inhibition mechanism in resistant pathogens?

Efflux pumps seems to be one of the resistant mechanism adopted by bacteria. Even though EPI's (efflux pump inhibitors) underwent more basic research and even clinical trials none of them have...

14 August 2014 3,239 3 View

Can anyone suggest the best chromatographic technique to be adopted to well separate high molecular weight tannins?

Used methods in the literatures include SEC and Prep.HPLC.

11 June 2014 1,168 3 View