I wish to conduct some experiments on rats with PCOS to study parthenogenesis!
Hi there. So, there is no ideal model to study PCOS - all of them have benefits and flaws. The most used ones are based on androgen therapy, especially during prenatal/neonatal periods in non-human primates. Others use genetic models and so on. However, these are rather expensive models that sometimes aren't available in places with low resources (we are currently facing this problem in Brazil). If you're looking for an effective and cheap model to study the metabolic pathways leading to PCOS, i.e. hyperinsulinemia, obesity and metabolic syndrome, then you might be interested in a paper we recently published. This is a model based on neonatal injections of this compound called MSG, often used as a food additive. If you have more questions or ideas, please send us a message. I'm always glad to talk about science! Hope this helps!
Dear Stefani ,
You may induce PCOS in rats by giving 1.0 mg/kg bwt Letrozole dissolved in 2.0 ml/kg b wt of 1% carboxymethylcellulose daily for 21 consecutive days. we followed the method described by Kafali et al., 2004). .
Since resource is a limitation in developing countries like India, I am looking for the most easily available model induced in rats. From the previous researchers I got that Letrozole dissolved in 2.0 ml/kg b wt of 1% carboxymethylcellulose daily for 21 consecutive days does the thing well. But, is their any easier protocol available to induce PCOS in rodents (Rats)?
At present I am using the administration of oestradiol valverate for the induction of PCO.
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