Since ADVina is a free software, you can download it at http://vina.scripps.edu/download.html

Download it using following link and follow installation details provided there.

http://vina.scripps.edu/download.html

In addition to the provided answers, since you are planning to run on Windows 10, you may also want to download a graphical user interface (GUI) software tool called MGLTools.

It is used to generate some input files and to visualise the results and ofcourse it is one of the specifically designed tools for use with AutoDock Vina.

MGLTools download: http://mgltools.scripps.edu/downloads

I cannot download autodock 4.2.3 and its executable files because the scripps.edu is down. Can anyone help?

Dear Mohammed Moustapha Anwar Abdallah , may I know which OS (windows, linux, or mac) are you using to conduct molecular docking using Autodock? I can provide you with the files only for windows and linux

Dear Farrah Wahidah Ridzwan , thank you for your reply. The operating system is windows. I would appreciate if you could help me with files. All I need the autodock software with its executable files.

Thanks!

Dear Mohammed Moustapha Anwar Abdallah, did you manage to ge the AutoDock Software? I really need it for a project I am working on but the server is still down. I also use windows. Could you help me?

Dear Anali De Luca , not yet. The server is still down. I really need it and I do not know what to do. I have looked up in the internet but there is no alternative.

Mohammed Moustapha Anwar Abdallah I found the archive website and managed to download it! https://web.archive.org/web/20190605111433/http://mgltools.scripps.edu/downloads

Dear Anali De Luca , the archive you mentioned contains only the MGLTools which are the pre-requisites for docking. But, where is the software itself (autodock 4.2.3 with its executable files). I do not see them. If you found it could you please share it with me?

Thanks!

Dear Mohammed Moustapha Anwar Abdallah , please obtain the file with the following link: http://autodock.scripps.edu/downloads/autodock-registration/autodock-4-2-download-page/

Dear Farrah Wahidah Ridzwan , thank you very much for your reply. However, the software is not working and the archive doe snot have the executable files which are necessary. Does it work with you?

Dear Mohammed Moustapha Anwar Abdallah , yes it works fine for me. The executable files can be find in The Scripts Institute under your Program Files folder if I'm not mistaken.

Hi Murad G Munahi

You can download autodock vina using the link

http://vina.scripps.edu/download.html

Also if you are looking for virtual screening, download cygwin (terminal) from the link.

https://cygwin.en.softonic.com/

Dear Farrah Wahidah Ridzwan , yes I can see the executable files but they are not working. I really need any help. The only program I know is autodock and I can use it easily. I am stuck.

Hi Mohammed Moustapha Anwar Abdallah , after installing if u get the two executables, ie atogrid.exe and autodock.exe. that is fine. it wont work if you try to open it.

What u have to do is to bring the pdb files needed to work in autodock into this location where u found the autogrid and autodock as well.

thank you

It does not work.

Mohammed Moustapha Anwar Abdallah , please explain what sort of error you'd encountered. Stating ''it doesn't work'' won't really help us to understand the issues you are currently having, let alone helping you to solve it. Please give us more to work on.

Dear Farrah Wahidah Ridzwan , this error appears after addung the ligand to MGLtools.

Dear Farrah Wahidah Ridzwan , I will share with you the protein pdbqt file and the ligand pdb file. Please try to do it to see if my laptop has any issue. I contacted the scripps institute and they acknowledged that their server is currently down.

Python 2.5.2 (r252:60911, Feb 21 2008, 13:11:45) [MSC v.1310 32 bit (Intel)] on win32

Type "copyright", "credits" or "license()" for more information.

****************************************************************

Personal firewall software may warn about the connection IDLE

makes to its subprocess using this computer's internal loopback

interface. This connection is not visible on any external

interface and no data is sent to or received from the Internet.

****************************************************************

IDLE 1.2.2 ==== No Subprocess ====

>>> Error parsing the following line in pdb:

HETATM 1 C LIG 1 16,000 -7,000 0,000 1.00 0.00 C

ERROR *********************************************

Traceback (most recent call last):

File "C:\Program Files (x86)\MGLTools-1.5.6\lib\site-packages\ViewerFramework\VF.py", line 898, in tryto

result = command( *args, **kw )

File "C:\Program Files (x86)\MGLTools-1.5.6\lib\site-packages\Pmv\fileCommands.py", line 803, in doit

mols = newparser.parse()

File "C:\Program Files (x86)\MGLTools-1.5.6\lib\site-packages\MolKit\pdbParser.py", line 657, in parse

self.pdbRecordParser[record](self.allLines, self.mol)

File "C:\Program Files (x86)\MGLTools-1.5.6\lib\site-packages\MolKit\pdbParser.py", line 431, in parse_PDB_atoms

at = self.parse_PDB_ATOM_record(atRec, mol)

File "C:\Program Files (x86)\MGLTools-1.5.6\lib\site-packages\MolKit\pdbParser.py", line 511, in parse_PDB_ATOM_record

atom._coords = [ [ float(rec[30:38]), float(rec[38:46]),

ValueError: invalid literal for float(): 16,000

ERROR *********************************************

Traceback (most recent call last):

File "C:\Program Files (x86)\MGLTools-1.5.6\lib\site-packages\ViewerFramework\VF.py", line 898, in tryto

result = command( *args, **kw )

File "C:\Program Files (x86)\MGLTools-1.5.6\lib\site-packages\AutoDockTools\autotorsCommands.py", line 996, in doit

numAts = len(m.allAtoms)

AttributeError: 'str' object has no attribute 'allAtoms'

Dear Farrah Wahidah Ridzwan , I have resolved the issue. I have a question to you. How could I know the active site of protein? Should I bring it from rcsb or what? is there a way to have it?