As M1 and M2 lie very close to each other, if I am going to do an implant to gather signals from only M1 neurons, is there any established way for me to locate accurately the M1 or M2?
The anatomical location of M1 and M2 can be referenced by the following:
http://www.sciencedirect.com/science/article/pii/S0166223699014861
http://www.neuroscience.ubc.ca/faculty/Murphy/images/NN%203499_Mohajerani_atlas.jpg
Thank you very much in advance!
From which parts of M1 do you wish to record? Vibrissal (whisker) M1? Or somatic (e.g. forelimb, hindlimb) M1?
Vibrissal M1 is medial to somatic M1. Secondary motor cortex (M2) appears to be anterior to somatic M1, in frontal cortex. This is according to a variety of recent studies (although how to define M2 functionally is not entirely clear). This is different from some atlas, e.g. Paxinos, which shows M2 medial to M1: the region labeled "M2" in many an atlas appears functionally to be vibrissal M1 (vM1). See for example papers by Svoboda and Petersen groups for location of vM1.
If you wish to record from vibrissal M1, rough coordinates are 1.0 anterior, 0.9 lateral to bregma. For somatic M1, you'd need to be more lateral, say 1.5 lateral to bregma.
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