Hi all, If anybody is using sorafenib (a multikinase inhibitor used as a chemotherapeutic agent in liver cancer, renal cell carcinoma etc.,) for in vitro studies? Literature suggests its solubility in DMSO is 200mg/ml. But in our lab it does not dissolve even at 1mg/ml (DMSO). It is not dissolving in water. If anybody has used it.. please let me know how you have worked with it?
Are you using powder or a tablette from the clincal setting? We dissovled it in DMSO at 10mM which worked fine for us.
We are using tablet which is used for clinical setting..Sorafenib tosylate (Nexavar;from Bayer and onyx) What did you use? @michael kiessling
Why don't you use pure chemical. The solubility is for pure chemical not for tablet. Usually tablet contains lots of other additives.
@Yong Weong Yi.. Thank you for the response. Yeah We are also thinking the same now.. We will ordering the pure chemical.. Do you sorafenib? If Yes from which company?
LC Laboratories is a good source with good price.
https://www.lclabs.com/
Youtake oh... Thank you for the response...Which sorafenib do you use?
what about solubility in water? ... or other solvent approriate for in vivo rodent studies
it is practically insoluble in water , DMSO is good solvent for this drug
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