How to design nano-particulate system to which water soluble protein drugs may be encapsulated with a thermodynamically favoured process and with preserved native conformation??
I have not participated in the design of the system, but have utilized a few processes to form nanoparticles - mostly nanoprecipitation by solvent evaporation/sublimation. With wanting to keep the water soluble protein in native conformation at all steps of the encapsulation process, I'd consider looking into properties of different solvents: density, hydrophilicity/phobicity, miscibility, pH, and salt content along with the solvent interactions with protein, monomers, and other solvents. Some resources I'd also consider:
http://www.nature.com/subjects/nanoparticle-synthesis
You have to use a good experimental design software for your work!
You can see my new publication in below link
Article Clove oil nanoemulsion as an effective antibacterial agent: ...
Thank you Jose & Md. Hassan for the valuable response. I will look for your given articles and will get back if anything needed..
Dear Gaurav
If you would like to ask me any specific question about it, please don’t hesitate about it.
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