is there a way to take advantage of plasma proteins as carriers?
or maybe by immune method using specific antibody?
if there are other ways I will be thankful for every suggestion..
What material? What kind of cells-- plant cells or animal cells? Plant cells have cell walls, making materials harder to get through.
Which type of cells are the target? DO you wan to make the delivery in vitro or in vivo? Cell culture or tissues?
G
thank you for interest ....... dr. Yuan and dr. Attila
I ask about animal cells in general.. there is no Specific project but For example, sometimes ask about the possibility of delivering a treatment material to hypothalamus cells. Think about a substance that can pass the brain barrier or some thing more easy like pancreas cells for the treatment of diabetes. all these ideas i wish to make it in vivo.
Targeted drug delivery, sometimes called smart drug delivery,[1] is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. These nanoparticles would be loaded with drugs and targeted to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with healthy tissue. The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue. The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug side-effects, and reduced fluctuation in circulating drug levels. The disadvantage of the system is high cost, which makes productivity more difficult and the reduced ability to adjust the dosages.
Targeted drug delivery systems have been developed to optimize regenerative techniques. The system is based on a method that delivers a certain amount of a therapeutic agent for a prolonged period of time to a targeted diseased area within the body. This helps maintain the required plasma and tissue drug levels in the body, thereby preventing any damage to the healthy tissue via the drug. The drug delivery system is highly integrated and requires various disciplines, such as chemists, biologists, and engineers, to join forces to optimize this system.[2]
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