How can I calculate entropy of a protein-ligand?

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Question:Did somebody used pSPYCE/pSPYNE vectors doing BiFC assays?

Somebody who knows why the two empty vectors I used as negative control, the fluorescence I can see under fluorescence microscope.

10 November 2017 4,135 7 View

How can you read .cel files using the R program?

Hello, Can anyone teach me how to read .cel files using the R program? I downloaded the expression data from EBI ArrayExpress database. They are .cel files. I know the R program can read it, but I...

10 November 2014 9,757 1 View

How can I study the promoters evolution?

I want to study the promoters evolution, but I have no idea how to research except for sequences alignment, constructing phylogenetic trees and finding the differences of TF binding sites. Could...

07 August 2014 6,113 3 View

Which methods is better for divergence time estimates?

Divergence time estimates are important to evolution research, but different estimated methods have various results. So I don't know which strategy of estimate is better and commonly used in...

06 July 2014 1,497 10 View

Can anybody help with a problem of molecular docking and autodock software?

When I used autodock to dock a protein and a molecular, a problem occured. The structure of small molecular is Fig A, but when I opened in autodock, it changed like Fig B. I don't know what...

04 May 2014 3,126 6 View

Which is the better tool or web server for protein structure prediction or homology modeling?

When I used I-TASSER, SWISS-MODEL, modeller homology modeling for my protein sequence, the results are much different, so I don't know which is the better. Anyone can give me some advice?

04 May 2014 4,802 3 View

How can I calculate natural evolution strategies (NES)?

Much research of adaptive evolution involves NES, but I don‘t know how to calculate it?

04 May 2014 4,741 1 View

How to use LIGPLOT software build a diagram like this?

I have a pdb file of a protein and a small molecules, respectively and I want to get a diagram like this figure, but I don't know how can I do it. I ask for your help if you have used this software.

04 May 2014 8,231 8 View

How can I discover SNPs from the upstream and downstream of gene?

I want to count all SNPs from the upstream and downstream of a gene and I have a reference genome sequence and all upstream and downstream sequence of the genes. However, I don't know how to...

02 March 2014 7,509 2 View

Are there instances where molecules with larger molecular weights exhibit greater mobility than those with smaller molecular weights?

Hi, I know that low molecular weight (MW) molecules generally tend to have higher mobility, while high molecular weight molecules tend to have lower mobility. However, in my experimental...

06 August 2024 1,495 2 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

How to start a Molecular Dynamics Simulation?

Is it possible to conduct a molecular dynamics simulation to see the effects of a specific carbohydrate on the structure of lipids (e.g., micelle structure)? I am a beginner in this field and plan...

03 August 2024 3,371 3 View

Which will be the best software for the Hydration shell analysis with molecular dynamics?

I am using a windows system, what software I should use for hydration shell analysis with molecular dynamics?

02 August 2024 3,143 4 View

Can anyone provide me with molecular docking softwares/ websites?

Molecular docking software/ websites?

02 August 2024 8,704 7 View

How to restart MD without using checkpint file in GROMACS?

Dear All Gromacs User I would like to restart MD without using checkpint .cpt files? I heard there is a way for acheiveing this. Any input and sugegstions are most welcome. Thanking You Budheswar

29 July 2024 3,084 8 View

AutoGrid and Autodock 4.2.6 window opens for 1 second then closes and there is no output files?

Good day, I am a student trying to work on Autodock for a project regarding Ligand-DNA interaction so i am quite new to molecular docking. i have followed tutorials and did all the steps...

28 July 2024 2,136 4 View

How to prepare a molecule for molecular dynamics calculations?

If I want to calculate molecular dynamics (Gromacs), do I first need to optimize the geometry of the molecule? For example, I first draw the molecule in Avogadro, and then what? I guess I can't...

28 July 2024 673 3 View

What exactly is it about biotechnology and medical research?

I'm very interested in biotechnology and medical research and I'd like to meet a professional here and talk about it together

28 July 2024 3,798 4 View

How does the Retention time effect the Biogas Production?

List down the various factors responsible and how does this effect the overall biogas production when it is related to Hydraulic retention time of the digester based on the feedstock?

27 July 2024 4,800 4 View