Hi to all, I have to dock a protein with a protein. I have determined the active residues by means of CSP.
I know that when the two proteins interact, share a copper ion, that is that is a sort of hinge for the monomers. In particular this copper ion binds to two cysteine her each monomer.
How can I block that cysteines during the docking?
The active residues on each monomer are different from the cysteine involved in the interaction with copper.
Thanks
Muhammad Sufian
As per my understanding, you do not want to include Cu-Cys resdues in interaction. In that case, if you do not mention them in active/passive residues then HADDock won't include them in interaction.
HTH.
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