I advice you to read more about dealing with lipopolysacharide as a nanoparticle to reduce from his toxicity effect

Hello, You can try different available kits/reagents for LPS removal from sample.

May be

see this link Article Bacterial endotoxin (lipopolysaccharide) binds to the surfac...

please see this articleArticle Bacterial endotoxin (lipopolysaccharide) binds to the surfac...

For the purpose of toxicity screening or biocompatibility testing of nanomaterials or mechanism studies on the possible toxicity induced by nanomaterials, various cell-based in vitro test systems and in vivo animal models are being developed and employed. In in vitro test systems, macrophages and other relevant mammalian cells are frequently used as the test cells especially for nanomaterials because they are primarily the responsible surveillance cells in the body. However, these cells are highly reactive to endotoxins; therefore it is difficult to distinguish the response to endotoxins from that to nanomaterials. Consequently, contamination by endotoxins would confound the result of tests in vitro.

Following

Article Bacterial endotoxin (lipopolysaccharide) binds to the surfac...