Hi guys,
I am currently writing my dissertation on the phagemid based delivery of CRISPR.
I'm currently looking at the limitations, specifically now looking at the immune response against phage. However, I'm struggling to see how phage is actually administered and where the immune response would occur.
Is the main route of transmission through the bloodstream, where antibodies and macrophages act on the phage and form a response or does this not occur?
Hi Ben,
The short answer is that it depends. Immune responses can differ depending on the phage. Topical or oral treatment have been used. There have been some very comprehensive reviews that can help address your question:
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Chapter Phage Interaction with the Mammalian Immune System
Article Interactions between Bacteriophage, Bacteria, and the Mammal...
Article Bacteriophage Interactions with Mammalian Tissue: Therapeuti...
Hello Ben,
Intravenous administration of phage therapy started in the 1940s.
Kindly read article titled " Safety and efficacy of phage therapy via the intravenous route" DOI: 10.1093/femsle/fnv242.
Furthermore, topical application also demonstrated no side effects, see the attached article
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