homologous recombination problem in gene targeting

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Frederick Christopher Chullai

Obviously, the mismatch will affect.

Brad Feilmeier

Depends on the organism. Neisseria and Strep don't have much problem. Anything else, probably.

Stephan A. Frye

Even in the Neisseriacea there are big differences and 10% sequence difference can drop the transformation frequency by several log10.