Hi, does any one know, how to calculate the mut. signatures for mouse mut. calls, any equivalent software like deconstructSig to do this? Many thank?

10 October 2017 1 6K Report

I have mutation calls for mouse genomes and i want to calculate the mutational signatures from these calls, I know how to do it for human genome using deconstructSig but i never came across a software specific for mouse genomes. Does anyone have any idea about this?

Arnoud Boot

there is no difference?

if you have the mutation calls, you can just calculate the number of mutations in each of the 96 classes.

if you want to compare with human signatures, you might want to compensate for trinucleotide context of the mouse vs human genome though, there could be some slight differences

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