Hereditary high grade glioma

01 January 1970 1 9K Report

Has anyone detected a hereditary cause in families with 3 first degree relatives with high grade glioma? We have a family with 3 siblings all with high grade glioma before age 45. No history in parents children or second degree relatives. Have assessed for TP53, and mis-match repair genes.

Muhammad Ali

It is still under question (to my experience it not hereditary), however., recently it gained great attention by the researchers, see for example : Article Genetic secrets of long-term glioblastoma survivors

https://www.healthline.com/health/brain-tumor/glioblastoma

https://moffitt.org/cancers/brain-cancer/faqs/are-all-gliomas-malignant/

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