It is reported by the Japanese newspapers that there is currently no cure for severe new coronavirus pneumonia. However, the severe condition could be improved by currently admitted drugs. I proposed the regimen but it was rejected by the Japanese Ministry of Health, Labor and Welfare.

Please share my article in the newspaper in your country.

The interesting thing about 2019-nCoV is that it not only increases pro-inflammatory cytokines but also results in elevated levels of IL-10 levels. As you know IL-10 is an anti-inflammatory cytokine. Although, further studies are needed to shed light on the cytokine profile of the patients. You may find further information here:

Article The Novel Coronavirus: A Bird’s Eye View

Thank you for information.

During the World War Japanese Government ordered Japanese people to fight against American Army with Bamboo spear .

At present, Ministry of Health, Labor and Welfare, Japan asked us to fight against 2019-novelCorona Virus (nCoV) Pneumonia with Bamboo spear such as washing hands, gurgle and face mask.

Dear Masato Hada

While SARS-CoV infects type 2 pneumocytes and ciliated bronchial epithelial cells utilizing angiotensin converting enzyme 2 as a receptor, and MERS-CoV exploits dipeptidyl peptidase 4 (DPP4), a transmembrane glycoprotein, to infect type 2 pneumocytes and unciliated bronchial epithelial cells, is hypothesized that 2019-nCoV virus might use angiotensin converting enzyme 2 as a receptor similar to SARS-CoV behavior. Similar to the findings in SARS-CoV infection, an increase in plasma pro-inflammatory cytokines levels has also been reported, correlating with the severity of the illness. However, increased levels of interleukin 10, which is an anti-inflammatory cytokine, suggest a pattern different from that of SARS-CoV infection. The cytokines storm as result of the infected epithelial cell, viral macrophage activation, and subsequently activated T cell. These mediators induce resting neutrophils to transition to cells primed for enhanced responses and finally to fully activated cells. Increase of peripheral blood neutrophils is observed in ICU infected patients respect to non-ICU patients (p

It is reported by the Japanese newspapers that there is currently no cure for severe COVID-19 Pneumonia. However, the severe condition could be improved by currently admitted drugs. I published an article today (Feb.20 2020) on how to treat the severe pneumonia. But my regimen is rejected by the Japanese Ministry of Health, Labor and Welfare. Please try to share my article in your country.

https://www.researchgate.net/publication/339375471_Chemotherapeutic_Strategy_with_Synbiotics_Thalidomide_and_Celecoxib_for_severe_COVID-19_Pneumonia_Association_between_microbiota_chronic_inflammation_and_pneumonia

In Japan, the use of antiflu drug Avigan for the treatment of the COVID-19 virus has started. It is theoretically effective in curbing the growth of the virus, however in mild cases natural cure could be possible. It is impossible to expect the benefits of Avigan for the patients with severe COVID-19 pneumonia. Drugs that act on NF-KB should be used.

In case of fire, firefighters discharge water to the fire. No measures are taken to cover the outside and prevent the spread of fire.

The bureaucrats of the Ministry of Health, Labor and Welfare of Japan has entered the last stage where they could work only with far inferior wisdom.

Reply from Ministry of Health, Labour and Welfare,Japan, Pharmaceutical Evaluation Division

Thank you for your cooperation.

This is the reply from Ministry of Health, Labor and Welfare, Pharmaceuticals and Health Department, Pharmaceutical Evaluation Division.

Sorry for your late response,

The following will be answered regarding the content of the inquiry, so please check it.

(Answer)

When conducting clinical trials in Japan, it is necessary to establish a system to plan and conduct clinical trials in accordance with the “Ministry Ordinance on Standards for Conducting Clinical Trials for Drugs”.

In addition, thalidomide, which is approved in Japan, is required to adhere to strict safety management procedures. For this reason, please consult with an approved thalidomide manufacturer and take appropriate action.

If you are conducting a clinical trial overseas, contact your local regulatory authority.

SARS-CoV1 and SARS-CoV2 envelope spikes protein viral adhesion glycoprotein are composed by two major types (L and S). In the SARS-CoV1, spike (S) protein is a 210- to 230-kDa glycoprotein with 23 potential N-glycosylation sites, while in SARS-CoV-2 the spike protein are prevalent composed by L and S types, with a different prevalence about 70% and 30% respectively. The S type is most likely the more ancient version of SARS-CoV-2, while the L type is a more evolute and more aggressive than the S type. Glycan analysis shows a wide range of structures, including complex N-glycans with 2 to 4 antennae capable of supporting ABH epitopes. Because the virus targets respiratory and gastrointestinal mucosa, it is highly likely that most human isolates express ABH antigens on the S protein and host envelope GSLs. Like the Env protein, S protein expressing A antigen can be blocked by monoclonal anti-A and human anti-A. Is probable that group O individuals are more resistant to SARS-CoV# due to ABO antibodies and could decrease the rate of infection throughout the population. Anti-A antibodies specifically inhibited the adhesion of SARS-CoV# S protein-expressing cells to ACE2-expressing cell lines. The degree of protection, may be influenced by the ABO antibody titer, secretor status, and incidence of group O in the population. Studies with human anti-A showed effective blocking with higher-titer anti-A (>1:256), while low-titer anti-A is ineffective. The latter condition can be invoked in the geographic area highly industrial, in which low ABO antibody titer are revealed that can be correlated with high levels of contagiousness. A nonsecretor phenotype would also nullify viral neutralization, since virus transmitted from a nonsecretor lacks ABH expression.

Considering distribution blood groups in Italy area

O A B AB

North 40% 44% 11% 5%

Central 39% 45% 12% 4%

South 41% 19% 28% 12%

is evident that high level of infected people are localized in north Italy, for high percentage of A type blood group and for probable low level of anti-A in individuals O-B types blood groups, connected to the industrialized area. In a short time, increase of the infected people will be evident in central Italy, that will condition the elevated value of contagious and dead people. While in the south, having a lower percentage of individual A group, and also a greater levels of anti-A are present in individuals, industrial less area, can be protective factor to infect. Therefore, blood group A, can be associated with an increased risk, whereas blood group O can be associated with a decreased risk, and that the ABO blood type can be a biomarker for differential susceptibility of SARS-ConV-2

Distribution blood groups in several countrys and SARS-ConV#

The infectious people are increasing (1000 + daily) in Japan. We Japanese were forced to fight American troops in bamboo spear in World War II. Now we are forced to fight with masks and social distance. Japanese Ministry of Health, Labor and Welfare (MHLW) is not trying to understand modern medicine and not to try to fight against CCOVID-19. The Japanese Government are taking ridiculous measures that the Minister of Economy, Trade and Industry is responsible for COVID-19 measures instead of MHLW. It probably happened because the government and Japanese people didn't believe in the bureaucracy of the MHLW.

Dear Masato

I should know. In Italy, we're in an identical situation. sic est!

"Whoever undertakes to set himself up as a judge of truth and knowledge is shipwrecked by the laughter of the gods."

Albert Einstein

Dr Zagami Francesco

Thank you for information and excellent recommendation.

http://gase.most.ntu.edu.tw/taiwancanhelp/national_item/29

Le Figaro - 9 septembre 2020

Covid-19 : « De nombreux rhumes sèment la confusion »

Le Pr Christophe Delacourt, président de la Société française de pédiatrie (SFP), remarque ainsi : « Il y a une grande discordance entre les propositions que nous avons faites sur la prise en charge des enfants symptomatiques et les décisions prises au cas par cas dans certaines écoles ».

Please read English version.

https://gase.most.ntu.edu.tw/articles/43A

Professor Chou told us that researchers in China have been extensively working on such research; meanwhile, Japanese physician, Masato Hada, also calling for a clinical trial of Thalidomide on COVID-19 patients in Japan. Professor Chou expressed, "sometimes with tragedies, good fortunes accompany them while good fortunes often have tragedies lurking beneath them." The once cursed medicine has successfully cured so many diseases, proving people that everything can be unpredictable, especially when it comes to medicine and the human body.

Excellent Dr. Masato Hada. Ganbaru!

Thank you Dr. Zagami Francesco. I will do my best. (Ganbarimasu)

You know Japanese?

Thank you again.

I don't know Japanese, only some philosophical expression!

I like a lot your culture.

Why not use the natural way to reduce proinflammatory cytokines ?

https://www.researchgate.net/post/Covid-19_Erythropoietin_EPO_deficiency_syndrome2

I have tried to convince danish medical authorities to do so. And I can report that irresponsible and ignorant bureaucrats are not confined to Japan.

However, I do not think thalidomide is an good idea, due to the adverse effects.

… 

Dear Mr Klaus Cort

I have treated more than six hundred far advanced cancer patients who are told to have palliative care for twenty years since 2000. Almost patients could be discharged with symptom improvements.

Adverse events

Teratogenesis

Side effects can be avoided unless thalidomide is used for men and women involved in pregnancy.

Clot formation

Thalidomide and Celecoxib have the action of clot dissolution. Therefore, clot on the artery lose the adhesion and go to small-diameter artery. It is important to use earlier and begin in a small amount.

Mechanism

Cancer initiation and cytokine storm of COVID-19 depend upon proinflammatory cytokines only differing in amount and term. Cytokine production is controlled by NF-kB.

Therefore, exacerbation of COVID-19 pneumonia is controlled by NF-kB. Thalidomide and celecoxib are the only small molecule drugs that can pass through cell membrane and directly suppress NF-kB activation. Thalidomide is a very effective and safe drug for professionals who understand the mechanism of thalidomide and who have ever used.

I hope you understand molecular mechanism, especially which pathways contribute to produce proinflammatory cytokines in complicated pathways from receptors to NF-kB quantitatively, not qualitatively.

Dear Masato Hada

I think that disease in Covid-19 is caused by the suppression of EPO by TNF-alpha. And the logic treatment is to supply exogenous EPO. - Just like diabetes is treated with insulin. Thalidomide like EPO suppresses NF-kB, but does it secure better maturation of red blood cells? Or improve the many other effects of EPO deficiency, that do occur in covid-19?

rhEPO offers an opportunity to intervene in the the "molecular circus" (of which you undoubtedly have a far deeper understanding than me) with a minimum of /no adverse effects.

Article Suppression of NLRP3 Inflammasome by Erythropoietin via the ...

https://www.researchgate.net/post/Covid-19_Erythropoietin_EPO_deficiency_syndrome2

Dear Mr Klaus Cort

I think I have to accept your suggestion, during cancer chemotherapy with thalidomide, celecoxib and cytotoxic agent, we experience anemia. But treatment with thalidomide and celecoxib we can continue the chemotherapy.

And for example, ACE2 is the receptor of corona virus, but anti ACE2 drugs are not effective at all.

Activated NF-kB produce more than four hundred proinflammatory cytokines such as interleukin-1β, IL-6 and TNF-α. At present only thalidomide and celecoxib can suppress NF-kB in the cell.

It is more important not to start a fire than to extinguish it.

Dear Masato Hada

Thank You for the very interesting information and the very pedagogical illustration, that even the worst bureaucrat should be able to understand (!).

Please read the comment.

Article Clinicopathologic and Immunohistochemical Findings from Auto...

In Japan, people's dissatisfaction exploded due to the inadequate measures againstCOVID-19 infection. A corporate advertisement was published in a national newspaper asking for an immediate solution.

ワクチンもない。クスリもない。タケヤリデ戦えというのか。このままじゃ政治に殺される。There is no vaccine. There is no medicine. Is it a fight with bamboo spear tactics? If we do nothing, politics will kill us soon.

All are believed to be due to the inability of Japanese Ministry of Health, Labor and Welfare bureaucrats.

https://twitter.com/asatte2015/status/1391888895776677891

There are case reports (pubmed) about thalidomide induced interstitial pneumonia in multiple myeloma patients and thalidomide drug must not be given with (a low supply of oxygen towards the heart as severe pneumonia disrupts oxygen to lungs and then heart) that it should not be administered to COVID patients (webmd.com who should not take thalidomide)

COVID induced pneumonia is challenge for whole world, we still can research for better and safe options to save patients with COVID severe pneumonia. I am not in favor for use of thalidomide to treat severe pneumonia in COVID patients.

Dr Nazia Asad

I hope you read my preprint.

Prevention and Treatment with Probiotics, Thalidomide, Celecoxib and Valproic Acid for COVID-19-induced pulmonary carcinoma.

My patient died due to pulmonary fibrosis, however the brain metastases had healed by thalidomide, celecoxib and cytotoxic agents.

Thalidomide do not effective to fibrosis do not exacerbate normal epithelium, therefore effective combination of drugs must be selected as soon as possible before the symptoms observed in COVID-19 pneumonia.

Why can't we use thalidomide to treat COVID-19 infection in Japan?

In 1999, I started cancer treatment with thalidomide and celecoxib. It was quite effective in treating cancer with a combination of molecular targeted drugs and small amount of cytotoxic drug.

However, in 2002, the Minister of Health, Labor and Welfare(MHLW) Chikara Sakaguchi of the Komeito Party（坂口力厚生労働大臣）and Tetsuya Kusakabe（日下部哲也: Chief of the Monitoring and Guidance Division of the MHLW), forged a violation of the Pharmaceutical Affairs Law. Thalidomide has been ordered to be recovered as a dangerous drug. After that, I applied for Chiken(治験：clinical trial in Japan), but Fujimoto Pharmaceutical(藤本製薬) was approved by Kazuhiko Mori (森和彦部長:その後大臣官房審議官, Director of the New Drug Review Department 1, and then Deputy Director-General of the Minister's Office). After that, I applied for Chiken (治験：clinical trial in Japan), but Fujimoto Pharmaceutical was approved by dictate of Haruo Yamashita (山下治夫former official: Director of the Law and Regulations Department), and Kazuhiko Mori. Thalidomide is now sold by Fujimoto Pharmaceutical, which has no development capabilities in Japan. From the above process, drugs that are considered to be effective against COVID-19 infection have been denied by incompetent, irresponsible politicians and bureaucrats, and 5 million people have been killed worldwide and more than 18,000 people have been killed in Japan.

I would like to report on the progress in sequence.

https://www.facebook.com/masato.hada.5/posts/4813076942139021

日本では何故サリドマイドを使用したコロナウイルス感染症治療ができないか？

サリドマイド回収命令から治験非実施指導まで

1999年からサリドマイドとセレコキシブを使用した癌治療を始めました。分子標的薬と抗癌剤を併用した癌治療でかなり効果的でした。

しかしながら2002年公明党坂口力厚生労働大臣と厚生労働省監視指導課日下部哲也係長が手を組んで薬事法違反を捏造しました。サリドマイドは危険な薬剤として回収命令が出され、その後、治験（日本の臨床試験）の申請をしましたが、藤本製薬が山下治夫法規部長の天下り工作で治験の承認が新薬審査第一部森和彦部長（その後大臣官房審議官）によって藤本製薬に許可され、サリドマイドは日本では開発能力の無い藤本製薬が販売権を得ることとなりました。

上記の経過から新型コロナウイルス感染症に有効と考えられる薬剤サリドマイドが能力の無い、無責任な政治家や官僚によって否定され全世界で500万人、日本で18000人以上の犠牲者が出ているのです。

順次経過をご報告したいと思います。

I understand that currently the COVID situation in Japan is at least under control.

Regarding the inability of the bureaucrats, I can guarantee you that in Italy the situation is much worse, because it goes beyond medical problems:

https://www.researchgate.net/post/COVID-19_state_lace

Fujimoto Pharmaceutical (藤本製薬)

The biggest cause of the great casualties caused by the tragic COVID-19 infection is that Fujimoto Pharmaceutical, which has no development ability, obtained the right to sell thalidomide in cooperation with Mr. Kazuhiko Mori (森和彦) of the Ministry of Health, Labor and Welfare with Amakudari (天下り: dictate) personnel.

Here is the Asahi Shimbun corporate advertisement.

Fujimoto Pharmaceutical (藤本製薬)seems to be prepared to drive a large number of cancer patients and COVID-9 patients to a tragic death in the millennium, "aiming to be a millennial company."

Fujimoto Pharmaceutical Group http://www.fujimoto-pharm.co.jp/

藤本製薬

悲惨な新型ウイルス感染症で多大な犠牲者を出した最大の原因は開発能力の無い藤本製薬が天下り人事で厚生労働省の森和彦氏と協力してサリドマイド販売権を得たのが最大の原因と考えられます。

ここに朝日新聞の企業広告があります。

藤本製薬は「千年企業をめざして」多数の癌患者並びにコロナウイルスウイルス患者さんをこの千年間で悲惨な死に追いやる心構えのようです。

藤本製薬グループ　 http://www.fujimoto-pharm.co.jp/

厚生労働省からの返事

2019年11月16歳の学生が2002年SARS、2012年MARSがあるからもうじきパンデミックが起こるねということでした。本人もメッカでMARSに感染し帰国した経験がありました。2019年11月厚生労働省にサリドマイドとセレコキシブを使用した癌治療や新型コロナウイルス治療法の可否を尋ねました。

国民を癌やコロナウイルス感染症から守ろうという責任感も意欲も感じない厚生労働省竹内聡氏からの返答でした。薬事法違反を捏造して回収命令を出し、治験禁止令を出して、再度治験準備を行えという全く矛盾した返答でした。サリドマイド薬事法違反のでっち上げ、治験禁止を伝える無責任な返答で膨大の癌患者さんや新型コロナ感染症で膨大の数の方が亡くなっていることに対する責任感を全く意識していないことは誠に残念なことです。

https://www.facebook.com/masato.hada.5/posts/4821858204594228

Masato Hada's Lab

In November 2019, I asked the Ministry of Health, Labor and Welfare about the possibility of cancer treatment and new coronavirus treatment using thalidomide and celecoxib.

We have done all that are asked legally. However, despite being not against the pharmaceutical law, we received thalidomide recall from 日下部哲也（Mr. Tetsuya Kusakabe, Chief of the Compliance and Narcotics Division, Ministry of Health, Labor and Welfare, Japan）.

In addition, 森和彦（Kazuhiko Mori）ordered to discontinue the clinical trial without showing legal basis, and the clinical trial of another pharmaceutical manufacturer 藤本製薬（Fujimoto Pharmaceutical）was approved by 天下り（Amakudari. “Amakudari” means descending from heaven）.

From the above process, drugs that are considered to be effective against COVID-19 infection have been denied by incompetent, irresponsible politicians and bureaucrats, and 5 million people have been killed worldwide and more than 18,000 people have been killed in Japan.

Why could not the Japanese government and the Ministry of Health, Labor and Welfare rescue patients with COVID-19 infection?

Cancer treatment with molecular-targeted drugs and cancer treatment with COVID-19 infection are quite the same and it can be applied to COVID-19 treatment (without ctotoxic drug). What they have in common is that they suppress NF-kB, which produces inflammatory cytokines. Currently, celecoxib and thalidomide are the only drugs that can effectively and safely suppress the activation of this protein. However, it should never be used by pregnant women or spouses. We applied for a clinical trial of this drug to the Ministry of Health, Labor and Welfare for the treatment of pancreatic cancer, but at the same time, the clinical trial of Fujimoto Pharmaceutical, which had no development ability, was specially approved. Results Low-level medical knowledge of MHLW officials has killed 5 million people worldwide and more than 20,000 in Japan.https://www.facebook.com/masato.hada.5/posts/4875516355895079

Youtube also seems to try to remove videos that are inconvenient to the authorities.

https://www.facebook.com/masato.hada.5/posts/4415164495263603

NHK (Japan Broadcasting Corporation) broadcasted my treatment with thalidomide negatively. I posted the video of the counterargument on Youtube, but it was deleted more than 10 years after it was posted.

Probably because the video pointed out the failure of the authorities to treat the COVID-19 infection.

It will be difficult for the Japanese administration to reduce the number of victims in the world, no, even in Japan.

https://www.facebook.com/masato.hada.5/posts/4724221351024581

Youtubeは当局に都合が悪いことは削除するという計らいもするようです。

私の治療法を否定的にNHKが放送しました。反論の動画をYoutubeに掲載しましたが掲載から十年以上してから削除されました。

動画が当局の新型ウイルス感染症治療の失敗を指摘するものであったためでしょう。

日本の行政では世界の、いや日本の犠牲者を削減させることは難しいでしょう。

厚労省監視指導課日下部哲也氏と兵庫県薬務課は、サリドマイド合成は薬事法違反であると何ら反論を聞かず強制的に回収命令を出しました。結果新型コロナウイルスに効果的なサリドマイドを使用した効果的治療ができず全世界で膨大の数の犠牲者が出続けています。下記の文献はサリドマイドの有効性を紹介しています。

Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312484/

Interestingly, due to its anti-inflammatory activity, Celecoxib in combination with thalidomide has also been suggested as a possible treatment of patients with severe COVID-19 pneumonia [39].

https://www.facebook.com/masato.hada.5/posts/4906275329485848

Thank you for recommendations to scientists in the world.

In Japan, Irresponsible and Ignorant Bureaucrats do not try to save lives of patients with CIVID-19 infection, continue to be ignorant and the infection have not ended. Asking us only wearing a mask and keeping social distance. As a result, more than 20,000 casualties continue to occur.

世界の科学者に感謝申し上げます。

日本では官僚の無知・無理解が続いておりコロナ感染症は終息していません。マスク着用、三蜜を唱え続けるだけです。その結果2万人以上の犠牲者が出続けています。

https://www.researchgate.net/profile/Masato-Hada/achievement/622198b70e467d59fccdaf53

サリドマイドの抗癌剤としての有用性を伝えようとNHKのクローズアップ現代の菅武仁ディレクターの取材に応じたものです。しかしながら本来の取材趣旨とあまりにも異なった内容が放送されたため、反論の動画をYoutubeに掲載しましたが削除されました。新型コロナウイルス治療にも有効ですが、厚労省とNHKの理解力欠如と無責任体制のため全世界で膨大な犠牲者を生んでいます。

In response to Close-Up Nowadays of NHK (菅武仁：National Broadcasting Institute, Japan) interview, I accepted the interview to convey the effectiveness of thalidomide as an anticancer drug. However, the content was so different from the original purpose of the interview, I posted the video of the counterargument on Youtube, but it was deleted. Thalidomide is also effective in treating COVID-19 infection, it has lead to enormous casualties worldwide due to the lack of understanding and irresponsibility of the Ministry of Health, Labor and Welfare and NHK.

https://www.facebook.com/masato.hada.5/posts/4909529052493809

分子標的薬としてサリドマイドは癌治療並びに新型コロナウイルス感染症に有効です。しかしながらNHKクローズアップ現代で「＊国谷裕子さんに怒られました part2」で非難中傷されました。厚労省（竹内聡氏）にもサリドマイドの使用を2019年11月に拒否されました。その結果NHKと厚労省は治療方法でなく莫大な数の感染者数（613万人以上）と死者数（2万7000人以上）を発表する役割しか担えなくなっています。

＊https://www.youtube.com/watch?v=TqAT568uc2c

I was scolded by the Caster Hiroko Kuniya (*国谷裕子さんに怒られました）on Close-Up Gendai (NHK).

As a molecular targeted drug, thalidomide is effective for cancers and COVID-19 infection. However, in Close-Up Gendai, I was accused in the program. The Ministry of Health, Labor and Welfare (厚労省：竹内聡：Satoshi Takeuchi) also refused to use thalidomide in November 2019 for COVID-19 infection. As a result, NHK and 厚労省 can only play a role in announcing a huge number of casualties (more than 6.13 million death in the world and more than 27,000 people in Japan).

* Https://www.youtube.com/watch?v=TqAT568uc2c

I think both 厚労省 and NHK were the same level of intelligence with this person.

https://twitter.com/hadaclinic/status/1341940550996353025

サリドマイド合成使用は薬事法違反として2002年厚労省の監視指導課日下部哲也係長によって回収命令が出されました。その結果、癌や難病に苦しむ患者さんを助けることができなくなりました。新型コロナウイルス感染症にも多剤併用で効果的です。

厚労省（竹内聡氏）にもサリドマイドの使用を2019年11月に拒否されました。その結果NHKと厚労省は治療方法でなく莫大な数の感染者数（581万3000人）と死者数（2万6000人）を発表する役割しか担えなくなっています。

全く事実と異なるストーリーを描き、取材内容を巧妙にすり替え、事件性を高めて、世間の注目を集める番組を作るそんな手法は許されるのでしょうか。

クローズアップ現代「やらせ」その手口とは　「国谷裕子さんに怒られました part3」ご覧ください。

https://www.facebook.com/masato.hada.5/posts/4966802443433136

In 2002, Tetsuya Kusakabe(日下部哲也), Chief of the Monitoring and Guidance Division of the Ministry of Health, Labor and Welfare (厚労省）issued a recovery order for the use of thalidomide as a violation of the Pharmaceutical Affairs Law. As a result, it has become impossible to help patients with cancers and intractable diseases. It is also effective for COVID-19 infection when used in combination with celecoxib.

Satoshi Takeuchi（厚労省：竹内聡) also refused to use thalidomide in November 2019. As a result, NHK and 厚労省can only play a role in announcing a huge number of infected people (6140,000 people) and deaths (28,000 people), not a cure.

Is it permissible to draw a story that is completely different from the facts, subtly replace the content of the interview, increase the incidentality, and create a program that attracts public attention?

Please see Close-Up Gendai "Yarase:やらせ" (faking non-event ) on the title "I was scolded by Hiroko Kuniya: part3".

https://www.facebook.com/masato.hada.5/posts/4966802443433136

Masato Hada

Dear Professor,

Thank you for initiating this interesting topic of discussion.

The bureaucrats are supposed to be generalists. The doctors are supposed to be specialists. There has been a serious degradation of the political leadership around the world. Today, in many parts of the world, we have weak personalities as leaders. They have chosen weaker persons to work under them as bureaucrats. Thus, the standard of bureaucrats have also gone down. In many places, we have weak, incompetent and not so educated people as bureaucrats. So, they are taking wrong decisions. In fact, I want to go a little further and tell you that in many cases they do not know the science of decision making. The result is for the whole world to see.

Best regards,

Anamitra.

Dear Masato Hada

What features of the molecular structure of Thalidomide do you think make it useful for treating COVID-19 infected people? That is, what is its mode of action?

Are there closely related molecules that might reduce inflammation damage?

https://en.wikipedia.org/wiki/Thalidomide

It is unpleasant truth - Following.

Dear Dr. Geoff Pain

Please read the following articles.

1. The Role of the Microbiome in Cancer Initiation and Progression: How Microbes and Cancer Cells Utilize Excess Energy and Promote One Another's Growth.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426824/

2. The cytokine storm of severe influenza and development of immunomodulatory therapy.https://www.nature.com/articles/cmi201574

3.Chemotherapeutic Strategy with Synbiotics, Thalidomide and Celecoxib for severe COVID-19 Pneumonia. Association between microbiota, chronic inflammation and pneumonia (my preprint on ReseachGate, which is cited by many articles. I wrote the molecular mechanism of thalidomide for the treatment of COVID-19 infection)

Best Regards

Masato Hada

毎日放送「ちちんぷいぷい」で放送されたサリドマイド回収命令に関する番組です。

厚生労働省監視指導課・兵庫県県庁から出された不当な回収命令を正当化する番組でしたが内容は庶民の気持ちを表現していると思います。

厚労省（竹内聡氏）にもサリドマイドの使用を2019年11月に拒否されました。その結果NHKと厚労省は治療方法でなく莫大な数の感染者数（615万人以上）と死者数（2万8000人以上）を発表する役割しか担えなくなっています。

https://www.facebook.com/masato.hada.5/posts/4771814042931978

It is a program related to the thalidomide recovery order issued by Tetsya Kusakabe (日下部哲也) broadcasted on the Daily Broadcast Company(毎日放送) "Chichin Puipui".

It was a program that justified an unjustified recovery order issued by 厚労省　日下部哲也/ Hyogo Prefectural Office, but I think the content expresses the feelings of the common people. The Ministry of Health, Labor and Welfare (厚労省：竹内聡：Satoshi Takeuchi) also refused to use thalidomide in November 2019 for COVID-19 infection. As a result, NHK and 厚労省 can only play a role in announcing a huge number of casualties (more than 6.15 million death in the world and more than 28,000 people in Japan).

Chichin Puipui"

A word that is chanted while stroking the painful area (by another person or yourself) when the infant hits his head against a pillar or falls and scrapes.

https://www.facebook.com/masato.hada.5/posts/4771814042931978

Please go through the link -https://www.google.com/url?sa=t&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjdoq-mxfz2AhXkR2wGHcb6BrUQFnoECAQQAQ&url=https%3A%2F%2Fwww.frontiersin.org%2Farticles%2F10.3389%2Ffimmu.2020.01248%2Ffull&usg=AOvVaw0A1f2Q04n9_ygMBt-FzCLe

National Yang-Ming University Chen-Kung Chou gently and kindly worried about the Japanese patients with COVID-19 infection.

TAIWAN CAN HELP

National Yang-Ming University Chen-Kung Chou (周成功兼任教授)

Scientists now think its mechanism could become a possible cure for pneumonia caused by the SARS-CoV-2 virus. Professor Chen-Kung Chou specializes in cytology and hepatitis, gave us a complete briefing about the relationship between Thalidomide and COVID-19.

"Thalidomide is a medicine full of surprise", he said.

Japanese physician Masato Hada discussed the possibility of using Thalidomide to treat COVID-19 patients. (Credit: ResearchGate/Masato Hada) https://gase.most.ntu.edu.tw/articles/43

國立陽明大學周成功教授は、日本のCOVID-19感染症患者を優しく親切に心配してくださいました。

台湾がお手伝いします

國立陽明大學周成功教授の解説

科学者たちは現在、SARS-CoV-2ウイルスによって引き起こされる肺炎のメカニズムが治療法つながる可能性があると考えています。 Chen-Kung Chou教授は細胞学と肝炎を専門としており、サリドマイドとCOVID-19の関係について完全な説明をしてくださいました。

「サリドマイドは驚きに満ちた薬です」と彼は述べています。

日本の医師、羽田正人は、サリドマイドを使用してCOVID-19患者を治療する可能性について述べています。 （出所：ResearchGate /羽田正人）

Please assist us to help Japanese and world people from COVID-19 infection with thalidomide and celecoxib.

I wrote the preprint on ResearchGate “Chemotherapeutic Strategy with Symbiotics, Thalidomide and Celecoxib for severe COVID-19 Pneumonia”.

Thalidomide and celecoxib are potently effective for COVID-19 infection.

Japanese government and Japan's Ministry of Health, Labor and Welfare (厚労省)denied to use thalidomide by their ignorance "that thalidomide is not effective and against pharmaceutical law".

See the TV shows (cancer treatment) on which I have been criticized in the past. Please understand how厚労省and the media, especially NHK, were arrogant and ignorant and have helped spread the coronavirus infection worldwide.

Some of my videos have been deleted from Youtube by A-PAB (The Association for Promotion of Advanced Broadcasting Services 一般社団法人放送サービス高度化推進協会), which is inconvenient for NHK and the authorities.

https://www.facebook.com/masato.hada.5/posts/4813076942139021

私はResearchGateに「重度のCOVID-19肺炎に対する、サリドマイド、セレコキシブによる化学療法」という論文を世界で初めて書きました。サリドマイドとセレコキシブはCOVID-19感染症に非常に効果的です。

日本政府と厚生労働省は、「サリドマイドは効果がなく、薬事法に違反している」という見地から、サリドマイドの回収命令と使用拒否しました。

テレビ番組を見る：各種がん治療にコロナ感染症と同様に有効であるのにマスコミの無知のため批判されてきました。 厚生労働とメディア、特にNHKがいかに傲慢で無知であり、コロナウイルス感染を世界中に広めるのに役立ったかを理解してください。世界では新型コロナ感染症で618万人、日本では2万8000人以上の方が亡くなっています。

私の動画の一部は、NHKや当局にとって不都合なのでしょう。A-PAB（高度放送サービス推進協会一般団章放送サービス昇化協会）によってYoutubeから削除されました（国谷裕子さんに怒られました）。

https://www.facebook.com/masato.hada.5/posts/4813076942139021

The treatment of new coronavirus (1 *) using thalidomide and celecoxib which I wrote has been introduced in many medical journals around the world. In Japan, thalidomide can no longer be used for fabrications that violate the Pharmaceutical Affairs Law by Mr. Tetsuya Kusakabe（日下部哲也）, Chief of the Monitoring and Guidance Division of the Ministry of Health, Labor and Welfare, and for NHK's Close-Up Gendai (now) with lie+ program by Mr. Takehito Suga (菅武仁). Ignorant and childish welfare bureaucrats (Tetsuya Kusakabe and Kazuhiko Mori) and unthinking media (2 * Close-Up Gendai lie +) have caused a great deal of casualties, the dead 6.18 million people worldwide, more than 28,000 people in Japan) for COVID-19 infection.

1＊Chemotherapeutic Strategy with Synbiotics, Thalidomide and Celecoxib for severe COVID-19 Pneumonia.

2＊https://www.facebook.com/masato.hada.5/posts/4745294948917221

私が書いたサリドマイドとセレコキシブを使用した新型コロナウイルス治療法（1＊）は世界の多くの医学雑誌に紹介されています。日本ではサリドマイドの厚労省監視指導課係長日下部哲也氏の薬事法違反捏造やNHKのクローズアップ現代の菅武仁氏による虚偽番組放送で使用できなくなりました。無知で幼稚な厚生官僚（日下部哲也氏や森和彦氏）と無思考なマスコミ（2＊クローズアップ現代嘘+）により多大な犠牲者（世界全体で618万人、日本では2万8000人以上の死者）が新型コロナ感染症で出ています。

Since 2000, I have treated about 600 patients with thalidomide and celecoxib for various cancers. However, the Government of Japan and the Ministry of Health, Labor and Welfare(厚生労働) have ordered the recovery and prohibition of thalidomide use from the viewpoint that "thalidomide is ineffective and violates the Pharmaceutical Affairs Law."

Watch TV program: Chikara Fukatsu(深津力), who had died with metastatic lung tumor, appeared on TV with his real name. He and I wanted to appeal to cancer patients widely by appealing the effect of thalidomide on cancer. However, NHK, which is ignorant of medical treatment, denied the effect and drove Mr. Fukatsu to death. The caster was Ms. Hiroko Kuniya(国谷裕子), who is famous castor in Japan. Thalidomide is also effective for COVID-19 infection, and many scientists around the world have read * my preprint.

* Chemotherapeutic Strategy with Synbiotics, Thalidomide and Celecoxib for severe COVID-19 Pneumonia.

Due to welfare labor (厚生労働)and the media, especially NHK's arrogance and ignorance,COVID-19 infection have spread around the world, more than 6.19 million people worldwide and 28,000 in Japan have been sacrificed.

https://www.facebook.com/masato.hada.5/posts/4799565206823528

私は2000年より約600人にサリドマイドとセレコキシブを使用した癌治療をおこないました。しかしながら日本政府と厚生労働省は、「サリドマイドは効果がなく、薬事法に違反している」という見地から、サリドマイドの回収命令と使用禁止を命令しました。

テレビ番組を見る：転移性肺腫瘍で瀕死の深津力さんは実名でテレビ出演してくださいました。サリドマイドの癌に対する効果を訴え広く癌患者さんに訴えたいという思いからでした。しかしながら医療に無知なNHKではその効果を否定し深津さんを死に追い込んでしまいました。キャスターは日本で有名な国谷裕子氏でした。新型コロナ感染症にも有効で、世界のたくさんの科学者にはその＊論文を読んでもらっています。＊Chemotherapeutic Strategy with Synbiotics, Thalidomide and Celecoxib for severe COVID-19 Pneumonia.

厚生労働とメディア、特にNHKが傲慢無知であるために、コロナウイルス感染症は世界中に拡散し、世界では619万人、日本では2万8000人以上の方が亡くなりつつあります。

https://www.facebook.com/masato.hada.5/posts/4799565206823528

Chikara Fukatsu(深津力), a patient with metastatic lung tumor, appeared on TV with his real name and appealed for the effectiveness and necessity of thalidomide. However, the thalidomide recovery order was forged and recovered by Mr. Tetsuya Kusakabe(日下部哲也) of the Ministry of Health, Labor and Welfare (厚労省: kouroushou in Japanese) as a violation of the Pharmaceutical Affairs Law, and the lives of the people following Mr. Fukatsu and the patients with COVID-19 infection were killed by 厚労省. More than 6.22 million people worldwide and more than 29,000 people in Japan has been sacrificed with COVID-19 infection. I posted this video because I wanted scientists in the world to know the magnitude of his responsibility of Mr. Tetsuya Kusakabe.

https://www.facebook.com/100003102888304/videos/3746322082147851/

転移性肺腫瘍の患者深津力さんは実名で顔を出してサリドマイドの有効性や必要性を訴えてくださいました。しかしながらサリドマイド回収命令は薬事法違反として厚労省の日下部哲也氏によって捏造・回収命令がだされ、深津さんに続く方々とコロナウイルスの患者さんの命は厚労省によって絶たれたのでした。新型コロナウイルス感染者で、全世界で622万人、日本で2万9000人以上の方々が犠牲になっています。この動画を投稿したのは、日下部哲也氏の責任の大きさを世界中の科学者に知ってもらいたいからです。

https://www.facebook.com/100003102888304/videos/3746322082147851/

This article proved that aspirin is effective in treating COVID-19 infection.

Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2790439

Aspirin, which has both COX-1 and COX-2 effects, is effective against COVID-19 infection. COX-1 is expressed in normal cells such as platelets, gastrointestinal tract, and kidney, and is necessary for homeostasis. COX-2 is an inflammation-inducing enzyme that expresses prostaglandin E2 (PGE2), which causes inflammation and pain. Therefore, aspirin suppresses COX-1 and COX-2 and has side effects. Celecoxib suppresses only COX-2, so it has few side effects.

I proposed the treatment for COVID-19 infection using thalidomide and celecoxib for the first time in the world. Unfortunately, it was denied by the Ministry of Health, Labor and Welfare (MHLW). Today, it is cited and introduced in famous medical journals around the world.

Chemotherapeutic Strategy with Synbiotics, Thalidomide and Celecoxib for severe COVID-19 Pneumonia.

The ignorance of MHLW bureaucrats must realize how horribly deadly the COVID-19 infection is.

日本語(Japanese)：

https://www.facebook.com/masato.hada.5/posts/5074294242683955

Article 2019 Novel Coronavirus (2019-nCoV) Pneumonia

Dear Dr. Javier Julian Enriquez and Dr. Jaydip Datta

Thank you for your precious reply and redommendation.

A textbook called Frontiers in Anti-Infective Agents: Volume 5 * introduces my treatment of COVID-19 infection [192]. I wrote about the importance of NF-κB in it, and I also explains its importance theoretically in this article. Unfortunately, Japanese bureaucrats of Ministry of Health, Labour and Welfare do not seem to have reading and understanding ability, and I think they have caused a huge number of deaths all over the world.

Frontiers in Anti-Infective Agents: Volume 5*という教科書に私の新型コロナウイルス治療法[192]が紹介されています。その中に NF-κB の重要性を書きましたが**本論文もその重要性を理論的に説明しています。残念ながら日本の厚生官僚には読解力がないようで全世界で莫大の数の死者を出していると思います。

*Frontiers in Anti-Infective Agents: Volume 5

A current analysis found that the integration of thalidomide and celecoxib, the selective COX-2 inhibitor, could boost extreme COVID-1-related pneumonia by modulating activated NF-κB that promotes extreme pulmonary injury [192].

現状の解析では、サリドマイドと選択的COX-2阻害剤であるセレコキシブの併用は、極度の肺損傷を促進する活性化されたNF-κBを抑制することにより、肺炎重症化を抑制する可能性があることがわかりました[192]。

**Transcription factor NF-κB as target for SARS-CoV-2 drug discovery efforts using inflammation-based QSAR screening model

NF-κB is a central regulator of immunity and inflammation. It is suggested that the inflammatory response mediated by SARS-CoV-2 is predominated by NF-κB activation. Thus, NF-κB inhibition is considered a potential therapeutic strategy for COVID-19.

NF-κBは免疫と炎症で中心的な役割を担っています。COVID-19によって引き起こされる炎症反応はNF-κBの活性化によって支配されています。 したがって、NF-κB抑制はCOVID-19感染症の大きな治療戦略と考えられています。

https://www.facebook.com/masato.hada.5/posts/5081608308619215

Dear Dr. Djénéba Traoré

Thank you for reading and recommendation.

Masato Hada,

Stop negative propaganda against Japan and its bureaucracy (They are reasonable and wise people).

Use of Thalidomide and celecoxib; is not approved by WHO; so, insisting upon using them doesn't make any sense.

Dr.Nazia Asad,

I have written the methods of treatments for immune disorders, cancers and viral infections according to scientific logic. Side effects can be overcome with medical science. Laws based on political and social logic cannot overcome natural science. It would be a shame if politics had an advantage over science in Pakistan.

In Japan as well, I received blame caused by ignorance. Although I wrote a cure for new coronavirus infection in November 2019, it was denied and resulted in huge casualties all over the world.

"EARL Medical Tweets

Rather, you are more suspicious, but what do you usually treat? Although the new corona virus did not occur in November 2019. What's more, for what did you try to use thalidomide, which has teratogenic and thrombosis as side effects? "

日本でも同じような無知による非難中傷はあります。2019年11月に新型コロナウイルス感染症治療法を書きましたが、有効性は否定されました。結果、全世界で膨大な犠牲者を出す結果になりました。

「EARLの医学ツイート

むしろあなたの方が怪しさ満点なんですが、普段何の治療してるんですか？だいたい2019年11月は新型コロナウイルスは発生していませんが。しかも催奇形性や血栓形成の副作用があるサリドマイドを何に使おうとしたんです？」

https://www.facebook.com/masato.hada.5/posts/4915880341858680

Clarivate, a British academic information company, has nominated for the Nobel Prize in Physiology or Medicine on the 21st by Dr. Hasegawa, Director of the Department of Adults, Tokyo Metropolitan Institute of Medical Science. Dr. Hasegawa discovered proteins that are pathological features of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), which are known as intractable diseases.

In May 2022, I wrote a treatment for ALS and posted it in ResearchGate "Prevention with Synbiosis and Treatment with Thalidomide and Celecoxib for Amyotrophic Lateral Sclerosis", which has been read by many scientists around the world. Unfortunately, due to the ignorance of the bureaucrats of the Ministry of Health, Labor and Welfare, this treatment cannot be performed in Japan. This is because thalidomide has been ordered to recall by Tetsuya Kusakabe（日下部哲也）, a health and welfare bureaucrat, as a violation of the Pharmaceutical Affairs Law.

英学術情報会社クラリベイトは2022年9月21日ノーベル賞医学生理学賞に東京都医学総合研究所の長谷川成人分野長を候補に挙げました。長谷川氏は難病として知られる筋萎縮性側索硬化症（ALS）と前頭葉側頭葉変性症（FTLD）の病理学的に特徴的であるたんぱく質を見つけました。

2022年5月ALSの治療法を書きReseachGate “Prevention with Synbiosis and Treatment with Thalidomide and Celecoxib for Amyotrophic Lateral Sclerosis”に掲載し世界の多くの科学者に読んでもらっています。残念ながら厚労省の官僚の無知のためこの治療法は国内では行うことができません。サリドマイドが薬事法違反として厚生官僚日下部哲也氏によって回収命令が出されたままになっているためです。

I wrote the treatment for COVID-19 in 2019-2020 and submitted it to ResearchGate. It has been quoted and introduced on SNS and in famous medical journals around the world. However, due to the ignorance of the bureaucrats of the Ministry of Health, Labor and Welfare, the effect is denied and a huge number of patients have been sacrificed by the ignorance of Japanese bureaucrats.

Preprint Chemotherapeutic Strategy with Synbiotics, Thalidomide and C...

I began the cancer treatment with thalidomide and celecoxib, even advanced symptoms are incredibly improved. This method is the first clinical application in the world, reducing growth of microblood vessels and is called molecular targeted therapy.

But I was asked to stop this treatment with thalidomide by Ministry of Health Labour and Welfare, Japan. They declaired that Cancer treatment with thalidomide was against the Pharmaceutical Affairs Law.

This TV program was telecasted to support the authority and to manipulate public opinion.

毎日放送「ちちんぷいぷい」で放送されたサリドマイド回収命令に関する番組です。

兵庫県県庁から出された不当な回収命令を正当化する番組で、批評を加えてビデオを作ってみました。

https://www.facebook.com/masato.hada.5/videos/690103241103099/

Please spread the Japanese situation to the people in the world.

IUPHAR/BPS guide to PHARMACOLOGY（＊1）

The IUPHAR/BPS Guide to PHARMACOLOGY is an open-access, expert-curated database of molecular interactions between ligands and their targets(＊2). Access this site and search for thalidomide, you can reach the preprint (DOI: 10.13140/RG.2.2.26979.91689) for COVID-19 infection that I wrote (*3). I am confident that it has been recognized worldwide as effective against COVID-19.

“An alternative approach is examining the combination of thalidomide + celecoxib (which targets NF-κB to suppress production of inflammatory cytokines; see preprint DOI: 10.13140/RG.2.2.26979.91689(*5)) (*3).”

Unfortunately, the Japanese Ministry of Health, Labor and Welfare (*4) could not understand the effectiveness and continues to cause great number of casualties in the world.(*5)

＊1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689838/

＊2 https://www.guidetopharmacology.org/

＊3 https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7327

＊4 https://www.facebook.com/memories/?source=notification¬if_id=1675809306106921¬if_t=onthisday&ref=notif

＊5 Chemotherapeutic Strategy with Synbiotics, Thalidomide and Celecoxib for severe COVID-19 Pneumonia. Association between microbiota, chronic inflammation and pneumonia (DOI: 10.13140/RG.2.2.26979.91689)

Youtubeでの出来事です。NHKのクローズアップ現代でのことです。

https://www.researchgate.net/profile/Masato-Hada/achievement/63e88304c719710a0c5c3ee0

Youtubeでの出来事です。NHKのクローズアップで現代放送された番組が事実と反することがあったのでYoutubeに投稿しました。NHKに不利との判断のためでしょうか、著作権に違反するということで私が投稿した番組は削除されてしまいました。

It's the Incident on Youtube. The content of the program was that synthesize and use of thalidomide are illegal and contrary to medicine. I posted the program on Youtube, because on the contrary to the facts, the NHK Close-Up Gendai program was broadcasted. They probably wanted to show a favorable judgment for NHK as copyright infringement. https://www.researchgate.net/profile/Masato-Hada/achievement/63e88304c719710a0c5c3ee0

サリドマイドは新型コロナ感染症に効果的です。私の書いた論文はSpringer Natureにも引用紹介されています。残念ながら日本経済新聞では兵庫県薬務課から当時医薬品でないのに医薬品と断定して回収命令が出され私達が薬事法違反をしたように報道されました。

https://www.nikkei.com/compass/content/NIRKDB20021106NKM0034/preview

薬剤師と医師の資格を持つものが、薬剤を製造・使用できないのであれば日本ではだれが医薬品製造を担うのでしょうか。

患者団体-坂口力厚生大臣-厚労省日下部哲也氏-兵庫県薬務課によって薬事法違反が捏造され回収命令は出され以後癌や各種難病に使用不可能となりました。

日本では新型コロナ感染症にセレコキシブとサリドマイド使用できず7万人以上の犠牲者が出ています。

https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7327

日本経済新聞に問い合わせましたが無回答です。https://support.nikkei.com/app/ask_0101/p/11

事実に沿った正確な訂正記事を出していただきたいと思います。

2019年11月4日コロナウイルスによるサイトカインストームに適応できる治療法を朝日新聞の「私の視点」に投稿してみました（＊1）。見事に却下されました（＊2）。

このたびは「私の視点」にご投稿いただき、ありがとうございました。

当欄はさまざまな分野の専門家のみなさまや、そのテーマに関心の深い方々からのご提言を掲載しておりますが、おかげさまで多くのご投稿が寄せられております。一定のスペースのなかで掲載できる数が限られており、なかなかご要望にお応えできないのが実情です。お寄せいただいたご投稿を検討させていただきましたが、今回は掲載を見送らざるをえませんでした。申し訳ございません。

せっかくご投稿をいただきながら恐縮ですが、今後ともどうぞよろしくお願い申し上げます。

朝日新聞オピニオン編集部視点係　Monday, November 4, 2019 1:44 PM

[email protected]

（＊1）

https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7327&fbclid=IwAR0k1cG1ErQHENCV-rVHHMXjCViptAWevOGRJ5Yo-Wqw7jzWM9AM3OLTBJA

（＊2）

https://www.facebook.com/masato.hada.5/posts/pfbid0CW6bVzCbHjhMdmNHfj9ze18Ai88nMXqR2XDNQAW39zguRzB1vN5VdxdbExustmeJl