Dear friend Manohar S K

Design of Experiments (DoE) is a statistical tool that can be used to optimize the formulation of nanocrystal-loaded orodispersible films. It is a very useful technique to gain synthetic control over nanocrystal characteristics compared to the traditional One Variable At a Time (OVAT) method (Efficient production of nanoparticle-loaded........ ).

The dependent variables in the preparation of nanocrystal-loaded orodispersible films include the drug release rate, disintegration time, and mechanical properties of the film. The independent variables include the concentration of the drug, type and concentration of polymer, plasticizer type and concentration, and surfactant type and concentration (Design of Experiments for Nanocrystal Syntheses....).

In addition, you may want to read my article.

Chapter Synthesis Of Manganese Oxide Nanoparticles Using Similar Pro...

Here are some references that you might find useful:

(1) Design of Experiments for Nanocrystal Syntheses: A How-To Guide for .... https://pubs.acs.org/doi/10.1021/acs.chemmater.2c02924.

(2) Resveratrol Nanocrystal Loaded Orodispersible Films: Formulation .... https://www.academia.edu/99371780/Resveratrol_Nanocrystal_Loaded_Orodispersible_Films_Formulation_Development_and_In_Vitro_Characterization.

(3) Efficient production of nanoparticle-loaded orodispersible films by .... https://pubmed.ncbi.nlm.nih.gov/27477101/.

(4) Development of Nanocrystal Ziprasidone Orally Disintegrating ... - Springer. https://link.springer.com/article/10.1208/s12249-020-01653-9.

(5) Designing Fast-Dissolving Orodispersible Films of Amphotericin B for .... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723921/.

May I add that attention to physicochemical properties be considered. Bonding affinity will influence disintegration time and also affect reaction time with surfactant. Density will also be relevant as a factor.