As per one recent research:

In patients with benign diseases, abnormal serum levels of HE4 and CA 125 were found in 1.1% (3 of 285) and 30.2% (86 of 285) of patients, respectively. CA 125 false positive results were mainly found in premenopausal women with abnormal serum levels in 32.3% of the patients with gynaecological benign diseases in contrast to 22% of them found in postmenopausal women. The use of ROMA algorithm reduces the proportion of CA 125 false positive results in the total group as well as in pre- or postmenopausal women