A few papers in the last 3-4 years have described protocols for deriving microglia, or at least microglia-like cells from mouse ES cells (Beutner et al, 2010; Napoli et al, 2009). These techniques do not appear to me to have been taken up significantly by the field. Has anybody tried these, or their own, and have any comments. I guess one issue is whether or not you can phenotypically prove that the cells are microglia, as opposed to monocyte/macrophage, but this should be getting easier with transcriptomic studies. This field is definitely lagging behind the neuronal and macroglial stem cell field.
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