Generally it was evidenced increase of IOP after each drug from antiVEGF family due to different mechanisms. To discuss presented case there is a need of additional information about the patient. Why he received Eylea injection ? Any ocular or systemic comorbidity, etc.

Say if a profusely leaking new vessel is being countered by eylea, it may perhaps contribute to a temporary decrease in iop.but as mentioned in the previous comment, has it been given in poag without other ocular disease??

as mac atrophy is a cause of concern in patients receiving anti vegf drugs chronically, shouldnt optic disc circulation be at a risk of compromise with eylea, thereby nullifying any useful impact of lower iop(if any at all).

You do raise an interesting line of enquiry though!!

Dear Carlo,

There are several studies reporting and increase in IOP after anti-VEGF injections. According to our research, this is a consequence of reduced outflow facility: http://iovs.arvojournals.org/article.aspx?articleid=2616206

Best,

Ester

Another side effects of IV antiVEGF discussed in enclosed paper

 Thanks a lot Marianne, Brijesh and Ester for your answers. The patients suffered from branch CRVO three years ago. Before Eylea her IOP was about 18-19 mmHg(G) with travoprost+brinzolamide+timolol+brimonidine. A week after the injection it fell to 9-10 mmHg(G). Maybe a "subclinical" "neovascularization (and as such undetected at gonioscopy performed some months before during a routine examination) of the iridocorneal angle might have been resolved or at least dramatically improved by aflibercept administration. Is it possible in your opinion? If it were the case, a potential new therapeutic application of antiVEGFs in treating neovascular glaucoma should be investigated.......

Possibly explanation for presented case could be Eyelea impacy on ciliary body, it's pigment epithelium decreasing production of aqueous humor causing drop in IOP

The tragedy of statins is that, like antihistamines, antitoxins, antibiotics and the millions spent searching for antivirals, all these drugs are poor vitamin C substitutes but the journals are closed to information that threatens drug profits so medical students and up are all ignorant. I have CURED GLAUCOMA , AMD and COPD and much more, free of the shackles of an Upper Tolerable Limit. Throw off the NHS slave master that murders patients (I was struck off for defending Public Health) Get FREE and practise HONEST medicine The Doctorate in CardioRetinometry   is now a 1 year (Part time) crash course for the D.CardioRet and can earn you $1m+/Year with your registrants locked in to pay you what an Optometrist charges $1.90/day on monthly Direct Debits $0-90cents from 1,500 registrants earn you $500,000/Year! .for 98% Risk Reduction of CHD thrombosis, stroke and 50% Life Extension. The first USA doctor qualifies May 2017with the extra DCardioRet and will be physicians to Presidents etc. [email protected] for info.

Thanks a lot Victor for your answer.

Best

Carlo