Has anyone used the kinase inhibitor JNK-IN-8 to successfully and selectively inhibit JNK in cultured cells?

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Anne von Koschembahr

I have used SP 600125 to successfully inhibit JNK activation in primary human skin cells. The concentration I used of this inhibitor is 15 um.

A. Petrov

I have used C29H29N7O2 - JNK-IN-8 (its a selective and irreversible type 2 inhibitor of JNK with IC50 value of 4.67 nM, 18.7 nM and 980 pM for JNK1, JNK2 and JNK3, respectively