Microbial resistance, allergy, gastrointestinal disturbances, etc are known complications of antibiotic use. Some of these complications may be preventable, but patients may be involved in tragic unprecedented accidents. These accidents my be under-reported probably due to medico-legal aspects especially in less developed countries.
Hi Najla,
Table 56-8 (Chapter 56) "Principles of Infectious Diseases" in "Applied Therapeutics: The Clinical Use of Drugs" By Mary Anne Koda-Kimble ., et al
may will answer your question.
Wish you all the best
Dear Najla,
Stevens-Johnson syndrome is a rare but very serious reaction to sulfa and penicillin compounds. It is not exclusively started by antimicrobials (anti-convulsants starts it frequently), but it may causes extense skin necrolysis that can evolve to septicemia and death.
Best regards
Recently observed a case of 6 years old was given antibiotics for gastrointestinal infection, the result was blood, present in stools, and then no antibiotic helped.
Thank you all for your answers. Nasir, you encountered a serious case of GI disturbance which was probably pseudomembranous colitis. What about you Marcelo and Yaser? Has any one of your patients had a complication?
Dear Najla. (Clarithromycin induced Rhabdomyolysis). The naranjo scale confirmed this adverse drug reaction. Rhabdomyolysis in this case was related to clarithromycin statin interaction.
Regards
During nearly 36 years of medical intensive care, we observed many antibiotics adverse effects such as allergy, Steven-Johnson, pseudomembranous colitis, aplasia, acute kidney injury secondary to aminoglycosides, for instance…
Within a prospective study, we demonstrated that about one third of our ICU patients treated with ampicillin have cytolysis at day 6-8.
With obstetricians and epidemiologists we reported that pregnant women admitted for preterm premature rupture of membrane treated with co-amoxiclav acquired P aeruginosa vaginal carriage, at median delay of 15 days ( 6- 42), leading to three fatal neonates fulminant sepsis.
A particular case report: a woman admitted for allergic shock associated with multi-organ failure secondary to one tablet of beta-lactamin prescribed for abdominal pain and a possible colitis and which required 36 hours of Norepinephrine. Unfortunately, distributive shock recurred on day 5 and despite intensive supportive treatment the patient died of peritonitis linked to previous hysterectomy performed 10 years before (compresses oversight).
Thus, never forget to track and to treat the initial disease which required antibiotic treatment…
Thank you Francois for your informative elaboration. You mentioned a number of antibiotics including co-amoxiclav which is associated with P aeruginosa. Can you elaborate more on that,or refer to the relevant published research? I also did not recognize the meaning of "cytolysis" and "beta-lactamin"
Dear Najla few years ago one of my patient get pseudomembranous colitis after adminestration of lincocine injection he was thirty years old and has been hospitilized foe=r few dayes and stop taking this antibiotic
Sorry for the "cytolysis" and beta-lactamin". instead of cytolytic hepatitis ( ALT > 3 normal ranges) and beta-lactams
Augmentin was responsible of acute hepatocellular injury : cell destruction within the first week of treatment, and thus of an cytolytic hepatitis, cholestatic complication were not observed, (usually at 2-3 week of treatment), maybe secondary to drug withdrawal?
For P aeruginosa vaginal colonisation, you may find the fulltext version of our report in my contributions and profile; Any how i send you a pdf version
Dear Maha, do you remember why the patient received lincomycin?
Thank you Maha. I wonder why dentists should prescribe lincomycin although it is not one of the recommended antibiotics for odontogenic infections.
Some antibiotic preparations can cause severe extravasation injuries, eg flucloxacillin. It is always a tragedy, especially when intravenous antibiotics were not required in the first place.
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