Is there any solvent out-of TBME, CPME etc., which can replace THF in cost and risk free in nature? Suggest some alternative solvents in-spite of THF.
There are several greener alternatives such as: diethoxymethane (DEM), various alkoxyethanols, Butyl diglyme (or diethylene glycol dibutyl ether), 2-methyl THF, and benzotrifluoride. I do not think many of these alternatives are considerably cheaper.
To David: Ph-CF3 is NOT green solvent (look at enviroment profile)
After H2O and CO2 , PEG, PPG and propylenecarbonate are most fit to green solvent definition. 1-methoxy-2-propanol, 3-methoxy-3-methyl-1-butanol and 2-methoxy-naphthalene are good as well.
Thank You Very much for your useful suggestions. Let me try these solvents for my work..
http://www.dbu.de/media/130508051211a525.pdf
This presentation contain a table of solvents preferred in green chemistry.
good luck!!!
I would start with 2-methyl THF, it has similar physical proprieties and is industrially produced from renewable source.
Good luck
2-Methyl THF is obvious environment-friendly in nature and could be better alternative to THF but it is costlier when compared to THF. It is good solvent for organic-water phase separations and low temperature reactions. So someone first check the reaction conditions before using 2-methyl THF.
Cost Effective greener solvents are H2O & ethylene glycol
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