Hello all
We have conducted a meta-analysis on diagnostic test accuracy studies that their method was similar to comparison method studies (We had data on index test, Reference test and the outcome was limits of agreement between the two methods to calculate precision). Simultaneous assessment of the two methods and setting were the two items important for us. The analysis was done with STATA 12.
For assessing the quality of studies, we have modified some of QUADAS-2 checklist questions but reviewers said that we must use GRADE approach too.
We have studies the GRADE guidelines. Unfortunately, we don’t understand how to do it and how to make specific questions in GRADE?
Any help would be greatly appreciated
Have you read about PICO framework? It consists of the following components:
- Patient: the patients or population to whom the recommendations are meant to apply
- Intervention: the therapeutic, diagnostic, or other intervention under investigation (e.g. the experimental intervention, or in observational studies the exposure factor)
- Comparison: the alternative intervention; intervention in the control group
- Outcome: the outcome(s) of interest
Based on the above framework, systematic review authors shall formulate their research topic or question
Dear Sara
I hereby send you 3 articles dealing with the how to use the GRADE approach in diagnostic studies - and I agree with Gopalakrishna et al that it is a challange bu doable
Gopalakrishna G, Mustafa RA, Davenport C, Scholten RJ, Hyde C, Brozek J, Schünemann HJ, Bossuyt PM, Leeflang MM, Langendam MW. Applying Grading of Recommendations Assessment, Development and Evaluation (GRADE) to diagnostic tests was challenging but doable. J Clin Epidemiol. 2014 Jul;67(7):760-8.
Singh S, Chang SM, Matchar DB, Bass EB. Chapter 7: grading a body of evidence on diagnostic tests. J Gen Intern Med. 2012;27 Suppl 1(Suppl 1):S47-55.
Schünemann HJ, Oxman AD, Brozek J, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ. 2008;336(7653):1106-10.
Best Carsten
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